CDH1 유전자 다형성 -160C_A와 대장결장암 발생에 관한 정량적 메타분석

조재승; 유미경; 박은정; 설재웅; 지선하

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자료유형: 학술저널

저자정보: 조재승 유미경 박은정 설재웅 지선하

저널정보: 한국보건정보통계학회 보건정보통계학회지 보건정보통계학회지 제35권 제1호

발행연도: 2010.1

수록면: 1 - 15 (15page)

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Purpose: Conflicting results on the association between cadherin-1 (CDH1) gene -160C>A polymorphism and risk of colorectal cancer have been reported. In order to clarify the effect of CDH1 polymorphism on the risk of colorectal cancer, we intended to perform a meta-analysis using published data. Methods: We attempted to search English literatures for all literat of possible effects of CDH-1 gene on colorectal cancer in human published prior to February 2010. We used a random effect model to perform a meta-analysis of 6 case-control studies that provided information related to the effects of CDH1 gene on colorectal cancer. Results: In a meta-analysis, a total of 13,278 participants (case: 6,603, control: 6,675) were included from selected 6 studies. From 5 studies for CDH1 -160C>A (rs16260) in relation to colorectal cancer, when compared with the reference genotype, the odds for CA genotype was 0.919 (0.858, 0.985; p = 0.017), whereas the odds for AA genotype was 0.800 (0.704, 0.909; p = 0.001). Similarly, from 2 studies for CDH1 -347G>A (rs5030625) in relation to colorectal cancer was 1.331 (1.029, 1.722; p =0.029). Conclusion: Our findings support that CDH1 -160C>A is significantly associated with colorectal cancer risk. Further studies are needed. Key words: Gene, Colorectal cancer, Cadherin-1, meta-analysis

#Gene #Colorectal cancer #Cadherin-1 #meta-analysis

참고문헌 (26)

참고문헌 신청

Aaltonen L / 2007 / Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors / Clin Cancer Res (13) : 356 ~ 361

Broderick P / 2007 / A genome-wide association study show that common alleles of SMAD7 influence colorectal cancer risk / Nat Genet (39) : 1315 ~ 1317

Cattaneo F / 2006 / Functional Analysis and Case-control study of -160C/A polymorphism in the E-cadherin Gene promoter: Association with cancer risk / Anticancer Resea (26)

Chen HC / 2003 / Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas / Cancer Lett (201) : 97 ~ 1

Cochran WG / 1954 / The combination of estimates from different experiments / Biometrics (10) : 101 ~ 129

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