지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 320 - 330 (11page)
이용수
초록· 키워드
오류제보하기
Porous nanosilica (PNS) has been identified as a potential candidate for controlled drug delivery. However, unmodified PNS-based carriers exhibited an initial release of loaded bioactive agents, which may limit their potential clinical applications. In this study, the surface of PNS was functionalized with adamantylamine (ADA) via disulfide bonds (-S-S-), PNS-S-S-ADA, which was then modified with cyclodextrin (CD)-heparin (Hep) (CDHep), PNS-S-S-CDH, for redox triggered rhodamine B (RhB) delivery. The obtained samples were then characterized by proton nuclear magnetic resonance (<SUP>1</SUP>H NMR), Fourier transform infrared (FTIR), and transmission electron microscope (TEM). These results showed that PNS-S-S-CDH was successfully formed with spherical shape and average diameter of 45.64 ± 2.33 nm. In addition, RhB was relatively encapsulated in the PNS-S-S-CDH (RhB@PNS-S-S-CDH) and slowly released up to 3 days. The release of RhB, in particular, was triggered due to the cleavage of -S-S- in the presence of dithiothreitol (DTT). It might be anticipated that the modified PNS can be used as redox-responsive drug delivery system in cancer therapy.
목차
Abstract
I. Introduction
II. Experiment
III. Results and Discussion
IV. Conclusion
References
참고문헌 (20)
참고문헌 신청
[학술지(정기간행물)] - I SLOWING / 2008 / Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers / Advanced Drug Delivery Reviews 60 (11) : 1278 ~ 1288
[학술지(정기간행물)] - Dai Hai Nguyen / 2016 / Hierarchical self-assembly of magnetic nanoclusters for theranostics: Tunable size, enhanced magnetic resonance imagability, and controlled and targeted drug delivery / Acta Biomaterialia 35 : 109 ~ 117
[학술지(정기간행물)] - Igor I. Slowing / 2009 / Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells / Small 5 (1) : 57 ~ 62
[학술지(정기간행물)] - Dai Hai Nguyen / 2013 / Bioreducible cross-linked Pluronic micelles: pH-triggered release of doxorubicin and folate-mediated cellular uptake / Journal of Bioactive and Compatible Polymers 28 (4) : 341 ~ 354
[학술지(정기간행물)] - Dai Hai Nguyen / 2011 / Disulfide-crosslinked heparin-pluronic nanogels as a redox-sensitive nanocarrier for intracellular protein delivery / Journal of Bioactive and Compatible Polymers 26 (3) : 287 ~ 300
[학술지(정기간행물)] - Dai Hai Nguyen / 2016 / Hierarchical self-assembly of magnetic nanoclusters for theranostics: Tunable size, enhanced magnetic resonance imagability, and controlled and targeted drug delivery / Acta Biomaterialia 35 : 109 ~ 117
[학술지(정기간행물)] - Igor I. Slowing / 2009 / Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells / Small 5 (1) : 57 ~ 62
[학술지(정기간행물)] - Dai Hai Nguyen / 2013 / Bioreducible cross-linked Pluronic micelles: pH-triggered release of doxorubicin and folate-mediated cellular uptake / Journal of Bioactive and Compatible Polymers 28 (4) : 341 ~ 354
[학술지(정기간행물)] - Dai Hai Nguyen / 2011 / Disulfide-crosslinked heparin-pluronic nanogels as a redox-sensitive nanocarrier for intracellular protein delivery / Journal of Bioactive and Compatible Polymers 26 (3) : 287 ~ 300
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
가솔린 입자상물질 규제 대응을 위한 터보과급 GDI 기관 및 실차 조건에서의 PN 배출특성
대한기계학회 춘추학술대회
2018 .06
-
Degradation of synthetic dye in water by solution plasma process
Journal of Advanced Marine Engineering and Technology (JAMET)
2016 .12
-
Performance Analysis on PN and Sequential Ranging for KPLO mission
한국항공우주학회 학술발표회 초록집
2017 .11
-
로다민 기반 염료감응형 태양전지의 제조 및 특성 분석
전기전자재료학회논문지
2015 .01
-
p형 Si(100) 기판 상에 안티몬 도핑된 n형 Si박막 구조를 갖는 pn 다이오드 제작 및 특성
반도체디스플레이기술학회지
2017 .01
-
Multi-Objective Calibration And Global Sensitivity Analysis Of Pn-Sbr Asm Model On In-Cycle Full-Scale Data
대한환경공학회 학술발표논문집
2021 .11
-
운행 경유자동차의 입자개수(PN) 검사 타당성 검토에 관한 연구
한국자동차공학회 춘계학술대회
2021 .06
-
Application of CBZ Dimer, C343 and SQ Dye as Photosensitizers for pn-Tandem DSCs
Electronic Materials Letters
2016 .01
-
인젝터 분무 패턴에 따른 가솔린 T-GDi 엔진의 PN 배출 특성 평가
KOSCO SYMPOSIUM 논문집
2019 .05
-
전기방사로 제작된 산화물 나노사 열전 pn 커플의 제작 및 특성
전기전자재료학회논문지
2015 .01
-
Controlling Morphologies of Redox-responsive Polymeric Nanocarriers for a Smart Drug Delivery System
한국고분자학회 학술대회 연구논문 초록집
2023 .10
-
일본 현대 건축의 PN-space적 특징에 관한 연구 : 동시대의 신진 건축가 4인의 작품을 중심으로
대한건축학회 논문집 - 계획계
2018 .04
-
pH-Responsive Polymers for Cancer Drug Delivery
한국고분자학회 학술대회 연구논문 초록집
2015 .04
-
자기센서 SNR 개선을 위한 초핑리스 오프셋 제거 및 PN-Code 모듈레이션
한국통신학회 학술대회논문집
2017 .06
-
Fabrication of TiO₂/g-C₃N₄ composites Prepared by Electrospinning for photocatalytic degradation of RhB
한국고분자학회 학술대회 연구논문 초록집
2018 .04
-
The relationship between various superplasticizers and hydration of mortar incorporating metakaolin
Journal of Ceramic Processing Research
2015 .04
-
하중에 따른 차량부품의 수명예측방법에 대한 연구
한국자동차공학회 추계학술대회 및 전시회
2017 .11
-
안테나 다이버시티를 이용한 PN 코드 획득 성능 분석
한국위성정보통신학회논문지
2017 .03
-
UTV용 가솔린 엔진에서 운전조건에 따른 PN 배출
한국자동차공학회 추계학술대회 및 전시회
2020 .11
-
Construction of Programmable Drug Delivery System with Additive Manufacturing
Journal of the Korean Society for Precision Engineering
2018 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-056-001660896