지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 500 - 505 (6page)
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초록· 키워드
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Colorectal cancer has become the third most common cancerand leads to high mortality worldwide. Although colorectalcancer has been studied widely, the underlying molecularmechanism remains unclear. PER3 is related to tumordifferentiation and the progression of colorectal cancer. Highexpression of miR-103 is associated with poor prognosis inpatients with colorectal cancer. However, the relationshipbetween miR-103 and PER3 in CRC cells remains unclear. Inthis study, we found that PER3 was downregulated in CRCtissues and CRC cell lines, whereas miR-103 was upregulatedin CRC cell lines. We also found that PER3 promoted CRCcells apoptosis. These results indicate that PER3 plays asuppressive role in CRC cells. Moreover, we found that PER3was targeted, at least partially, by miR-103. Taken together, weprovide evidence to characterize the role of PER3 in CRC, which may be a new therapeutic target for CRC.
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참고문헌 (22)
참고문헌 신청
Gery, S. / 2007 / The role of circadian regulation in cancer / Cold. Spring. Harb. Symp. Quant. Biol 72:459~464
Buhr, E. D / 2013 / Molecular components of the Mammalian circadian clock / Handb. Exp. Pharmacol 217:3~27
Wang, X. / 2012 / Reduced expression of PER3 is associated with incidence and development of colon cancer / Ann. Surg. Oncol 19:3081~3088
Matsuo, T. / 2003 / Control mechanism of the circadian clock for timing of cell division in vivo / Science 302:255~259
Calin, G. A. / 2006 / MicroRNA signatures in human cancers / Nat. Rev. Cancer 6:857~866
Buhr, E. D / 2013 / Molecular components of the Mammalian circadian clock / Handb. Exp. Pharmacol 217:3~27
Wang, X. / 2012 / Reduced expression of PER3 is associated with incidence and development of colon cancer / Ann. Surg. Oncol 19:3081~3088
Matsuo, T. / 2003 / Control mechanism of the circadian clock for timing of cell division in vivo / Science 302:255~259
Calin, G. A. / 2006 / MicroRNA signatures in human cancers / Nat. Rev. Cancer 6:857~866
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