메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Skin aging is induced by intrinsic and extrinsic factors, such as a senescence, UV, IR, oxidative stress, etc.. Intrinsic and extrinsic factors induced decrease of collagen expression and increase of MMP1 expression by these factors. Especially, decrease of collagen induces skin aging and formation of wrinkles. Sericin, major ingredient protein of silk synthesized by silk worm, induce increase of collagen and decrease of MMP1 and used collagen substitute in cell culture. In addition, alpha-mangostin is one of major ingredients in mangostin. In our study, we investigated whether alpha-mangostin induced synergetic effects with sericin on collagen type 1a1 expression and anti-wrinkle effects. In vitro study, sericin only induced collagen type 1a1 expression in human dermal fibroblasts (HDFs). However, cotreatment with alpha-mangostin reinforced increase of collagen type 1a1 expression in sericin-treated HDFs. In addition, to evaluate efficacy on aging skin phenomena, clinical efficacy trials were conducted using Antera 3D. Improvement of wrinkle was assessed using ANTERA 3D. Results of clinical efficacy shown that sericin and alpha-mangostin contained mask decreased wrinkle depth of crow´s-feet in using time dependent manner. Overall, sericin and alphamangostin synergistically improves ECM structure using increase of collagen expression. These results suggest combination with sericin and alpha-mangostin as a new, effective anti-aging cosmetic ingredient.

목차

등록된 정보가 없습니다.

참고문헌 (22)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0