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Anti-wrinkle and Skin turnover Improvement Effects of Niacinamide-dipeptide Convergence
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나이아신 펩타이드 융합체의 항주름 및 피부 턴오버 개선 효과

논문 기본 정보

Type
Academic journal
Author
Journal
한국피부과학연구원 아시안뷰티화장품학술지 아시안뷰티화장품학술지 제16권 제2호 KCI Accredited Journals
Published
2018.1
Pages
243 - 254 (12page)

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Anti-wrinkle and Skin turnover Improvement Effects of Niacinamide-dipeptide Convergence
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Purpose: This study aimed to determine the anti-wrinkle and skin turnover improvement effects of niacinamide-dipeptide convergence (N-peptide). Methods: The following methods were employed to assess the anti-wrinkle and skin turnover improvement effects of N-peptide: 3-(4,5-Dimethylthiazol-2- yl)-2,5-diphenyltetrazolium bromide (MTT) assay, wound healing assay, chicken chorioallantoic membrane (CAM) assay, reverse transcription polymerase chain reaction (RT-PCR), and three-dimensional (3D) cell culture. Results: The MTT assay revealed that the N-peptide does not exert a cytotoxic effect in human keratinocytes (HaCaT). Moreover, the scratch wound healing and CAM assays showed that the N-peptide induced migratory properties and angiogenesis, respectively, in HaCaT cells. The expression of matrix metalloproteinases (MMP)-1, -2, -3, and -9 was measured using RT-PCR to evaluate the anti-wrinkle effect of N-peptides. The findings demonstrated that N-peptides were responsible for reducing the expression of the aforementioned MMPs. In addition, using western blotting, N-peptides were identified to increase energy metabolism activity. Furthermore, 3D cell culture analysis indicated improvement in the skin turnover rate because of the N-peptides. Conclusion: Taken together, these results suggest that N-peptides may be a source of cosmetic agents for the improvement of wrinkles and skin turnover.
#Niacin-dipeptide convergence #Functional cosmetic #Anti-wrinkle #Skin barrier #Skin turnover rate

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References (27)

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정명근 / 2013 / 맥문동 종실 안토시아닌 분획물의 멜라닌 생성 억제 및 미백 효과 / 한국약용작물학회지 21(5):361~371 dbpia Hardie DG / 2012 / AMPK: a nutrient and energy sensor that maintains energy homeostasis / Nature Reviews. Molecular Cell Biology 13:251~262 google schola 전민희 / 2011 / 적송잎 추출물이 항산화 활성 및 파골세포의 증식에 미치는 영향 / 한국식품영양과학회지 40(4):525~530 dbpia 전영선 / 2009 / 콜라겐 섭취가 안면피부 주름에 미치는 영향 / 아시안뷰티화장품학술지 7(2):79~94 dbpia 정해수 / 2015 / 갈릭산 펩타이드 유도체를 이용한 주름개선 소재 개발 / 한국산학기술학회논문지 16(8):5452~5457 dbpia

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