지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 361 - 371 (11page)
이용수
이 논문의 연구 히스토리 (2)
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
This study was performed to determine the antimelanogenic effect and tyrosinase inhibitory activities of anthocyanin rich fraction (AN-SLP) from Liriope platyphylla Wang et Tang seeds. Anthocyanins isolated from L. platyphylla seeds revealed the presence of four major anthocyanin components, which were tentatively identified as delphinidin-3-Oglucoside,delphinidin-3-O-rutinoside, petunidin-3-O-rutinoside, and malvidin-3-O-rutinoside using semipreparative HPLC,1H-NMR, 13C NMR, FAB-MS and LC/ES-MS. The inhibitory effect of AN-SLP on tyrosinase activity was studied using in vitro (against mushroom tyrosinase) and ex vivo (against B16 melanoma cell tyrosinase) models. Cellular tyrosinase activity was decreased by AN-SLP treatment in B 16 melanoma cells through dose dependent manner, but AN-SLP did not inhibit mushroom tyrosinase and L-DOPA oxidation directly. AN-SLP showed melanin inhibition by 53.2% at 50 ㎍/㎖ which was 0.7 times more efficient than the antimelanogenic effect of commercial arbutin and kojic acid (36.5%) also did not show cell toxicity. Additionally, AN-SLP inhibited the activity of α-glucosidase and the glycosylation of tyrosinase in melanoma cell. The resulting unsaturated glycosylation of tyrosinase makes it unstable and disturb correct transportation. From theses results, we conclude that AN-SLP could be used as anti-melanogenic agent for skin whitening.
목차
등록된 정보가 없습니다.
참고문헌 (45)
참고문헌 신청
Alaluf S / 2001 / Variation in melanin content and composition in type V and VI photoexposed and photoprotected human skin: The dominant role of DHI / Pigment Cell Research 14:337~347
Aramwit P / 2010 / The properties and stability of anthocyanins in mulberry fruits / Food Research International 43:1093~1097
Battaini G / 2000 / Inhibition of the catecholase activity of biomimetic dinuclear copper complexes by kojic acid / Journal of Biological Inorganic Chemistry 5:262~268
Branza-Nichita N / 2000 / Mutations at critical N-glycosylation sites reduce tyrosinase activity by altering folding and quality control / Journal of Biological Chemistry 275:8169~8175
Branza-Nichita N / 1999 / Tyrosinase folding and copper loading in vivo: A crucial role for calnexin and alpha-glucosidase II / Biochemical and Biophysical Research Communications 261:720~725
Aramwit P / 2010 / The properties and stability of anthocyanins in mulberry fruits / Food Research International 43:1093~1097
Battaini G / 2000 / Inhibition of the catecholase activity of biomimetic dinuclear copper complexes by kojic acid / Journal of Biological Inorganic Chemistry 5:262~268
Branza-Nichita N / 2000 / Mutations at critical N-glycosylation sites reduce tyrosinase activity by altering folding and quality control / Journal of Biological Chemistry 275:8169~8175
Branza-Nichita N / 1999 / Tyrosinase folding and copper loading in vivo: A crucial role for calnexin and alpha-glucosidase II / Biochemical and Biophysical Research Communications 261:720~725
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-480-000587456