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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 88 - 91 (4page)
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After introducing tyrosine kinase inhibitors (TKIs) as promising treatments for radioactive iodine refractory advanced thyroid cancer patients, we more often meet patients with TKI-related hormone and electrolyte imbalances in clinics. Hypocalcemia associated with TKI is associated with an imbalance in calcium-vitamin D metabolism. TKI-related hypothyroidism is related to the metabolic rate of thyroid hormones. The two side effects usually occur in the early stages of TKI treatment, and if the imbalance is corrected appropriately, the effects are minor, but in severe cases, the TKI should be discontinued. The authors reported a case of severe hypocalcemia and thyroid dysfunction after TKI treatment. A 56-year-old man suffered from symptomatic hypocalcemia during TKI treatment, which was resolved after he stopped taking the TKI medication. Although calcium and vitamin D replacement have increased, hypocalcemia was recurred and TKI treatments have been permanently stopped due to serious weight loss in grade 3. After the interruption, his calcium levels normalized.
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참고문헌 (23)
참고문헌 신청
Schlumberger M / 2015 / Lenvatinib versus placebo in radioiodinerefractory thyroid cancer / N Engl J Med 372(7):621~630
Brose MS / 2014 / Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial / Lancet 384(9940):319~328
Kawalec P / 2016 / Lenvatinib for the treatment of radioiodine-refractory differentiated thyroid carcinoma: a systematic review and indirect comparison with sorafenib / Expert Rev Anticancer Ther 16(12):1303~1309
이가희 / 2016 / 2016년 대한갑상선학회 갑상선결절 및 암 진료 권고안 개정안 / International Journal of Thyroidology 9(2):59~126
Haugen BR / 2016 / 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer / Thyroid 26(1):1~133
Brose MS / 2014 / Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial / Lancet 384(9940):319~328
Kawalec P / 2016 / Lenvatinib for the treatment of radioiodine-refractory differentiated thyroid carcinoma: a systematic review and indirect comparison with sorafenib / Expert Rev Anticancer Ther 16(12):1303~1309
이가희 / 2016 / 2016년 대한갑상선학회 갑상선결절 및 암 진료 권고안 개정안 / International Journal of Thyroidology 9(2):59~126
Haugen BR / 2016 / 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer / Thyroid 26(1):1~133
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