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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 169 - 177 (9page)
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Purpose Despite the successful use of tyrosine kinase inhibitors (TKIs) in cancer patients, their effect on herpes zoster development has not been studied. The aim of this study was to evaluate and compare the effects of epidermal growth factor receptor (EGFR) TKI and cytotoxic chemotherapy on the risk of herpes zoster development in non-small cell lung cancer (NSCLC) patients. Materials and Methods We conducted a medical review of all eligible NSCLC patients in Seoul National University hospital between 2002 and 2015. We classified patients based on whether they previously underwent EGFR TKI therapy into either the TKI group or the cytotoxic group. We compared the incidence rates of herpes zoster during TKI therapy and cytotoxic chemotherapy. Additionally, the longitudinal risk of herpes zoster from TKIs was analyzed using the incidence rate ratio (IRR) of the TKI group to the cytotoxic group and the log-rank test of the Kaplan- Meier method. Results Of the 2,981 NSCLC patients, 54 patients (1.54%) developed herpes zoster. In the TKI group (2,002 patients), the IRR of herpes zoster during TKI therapy compared to that during cytotoxic chemotherapy was 1.05 (95% confidence interval [CI], 0.53 to 2.09). The IRR of the TKI group compared to the cytotoxic group was 1.33 (95% CI, 0.64 to 2.76). The Kaplan- Meier cumulative risk of both groups was not significantly different. Conclusion Our results show that the incidence rate of herpes zoster in the TKI group was not statistically different from the incidence in the cytotoxic group during and after chemotherapy in NSCLC patients.
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참고문헌 (26)
참고문헌 신청
Pinchinat S / 2013 / Similar herpes zoster incidence across Europe : results from a systematic literature review / BMC Infect Dis 13:170
Yawn BP / 2007 / A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction / Mayo Clin Proc 82:1341~1349
Thomas SL / 2004 / What does epidemiology tell us about risk factors for herpes zoster? / Lancet Infect Dis 4:26~33
Rifkind D / 1966 / The activation of varicella-zoster virus infections by immunosuppressive therapy / J Lab Clin Med 68:463~474
Glesby MJ / 1995 / Clinical spectrum of herpes zoster in adults infected with human immunodeficiency virus / Clin Infect Dis 21:370~375
Yawn BP / 2007 / A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction / Mayo Clin Proc 82:1341~1349
Thomas SL / 2004 / What does epidemiology tell us about risk factors for herpes zoster? / Lancet Infect Dis 4:26~33
Rifkind D / 1966 / The activation of varicella-zoster virus infections by immunosuppressive therapy / J Lab Clin Med 68:463~474
Glesby MJ / 1995 / Clinical spectrum of herpes zoster in adults infected with human immunodeficiency virus / Clin Infect Dis 21:370~375
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