지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.96 No.4
- 발행연도
- 2019.4
- 수록면
- 177 - 184 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Routine supplementation of high-dose calcium significantly decreased the risk of postoperative symptomatic hypocalcemia after thyroidectomy. However, there is an ongoing debate about whether the same results can be achieved with low-dose calcium supplementation.
Methods: Patients (n = 138) who underwent total thyroidectomy for thyroid cancer were 1:1 randomly assigned to receive oral supplements of 1,500 ㎎/day elemental calcium and 1,000 IU/day cholecalciferol for 2 weeks or no supplementation. Primary objective was to compare the incidence of symptomatic hypocalcemia for 3 days after total thyroidectomy. Secondary objective was to find the predictors for postoperative hypocalcemia in patients with thyroid cancer.
Results: Sixty-five patients in the calcium group and 69 patients in the control group were finally analyzed. The incidence of symptomatic hypocalcemia showed no difference between the calcium and control group (32.3% vs. 21.7%, P = 0.168). The total dosage of intravenous calcium (593.4 ± 267.1 ㎎ vs. 731.6 ± 622.7 ㎎, P = 0.430) administered to patients with symptomatic hypocalcemia was also comparable between groups. In a multivariate analysis, parathyroid hormone level of 13 pg/mL at postoperative day 1 was only predictive for symptomatic hypocalcemia, and its incidence was 20.9 times (95% confidence interval, 6.8–64.5) higher in patients with parathyroid hormone <13 pg/mL. Other factors did not predict the development of hypocalcemia, including clinicopathological features and routine supplementation of low-dose calcium.
Conclusion: Routine low-dose calcium supplementation did not reduce the risk of postoperative hypocalcemia. Patients who may benefit from calcium supplementation should be carefully selected.
Methods: Patients (n = 138) who underwent total thyroidectomy for thyroid cancer were 1:1 randomly assigned to receive oral supplements of 1,500 ㎎/day elemental calcium and 1,000 IU/day cholecalciferol for 2 weeks or no supplementation. Primary objective was to compare the incidence of symptomatic hypocalcemia for 3 days after total thyroidectomy. Secondary objective was to find the predictors for postoperative hypocalcemia in patients with thyroid cancer.
Results: Sixty-five patients in the calcium group and 69 patients in the control group were finally analyzed. The incidence of symptomatic hypocalcemia showed no difference between the calcium and control group (32.3% vs. 21.7%, P = 0.168). The total dosage of intravenous calcium (593.4 ± 267.1 ㎎ vs. 731.6 ± 622.7 ㎎, P = 0.430) administered to patients with symptomatic hypocalcemia was also comparable between groups. In a multivariate analysis, parathyroid hormone level of 13 pg/mL at postoperative day 1 was only predictive for symptomatic hypocalcemia, and its incidence was 20.9 times (95% confidence interval, 6.8–64.5) higher in patients with parathyroid hormone <13 pg/mL. Other factors did not predict the development of hypocalcemia, including clinicopathological features and routine supplementation of low-dose calcium.
Conclusion: Routine low-dose calcium supplementation did not reduce the risk of postoperative hypocalcemia. Patients who may benefit from calcium supplementation should be carefully selected.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
갑상선 유두암 환자의 전절제술 후 부갑상선 기능 저하증의 위험 인자
The Journal of Endocrine Surgery
2016 .01
-
Clinical Study of Post Thyroidectomy Hypocalcemia
The Journal of Endocrine Surgery
2023 .06
-
Causes and Clinical Features of Transient Hypocalcemia in Newborn: A Single Center Study
Neonatal medicine
2016 .01
-
Percentage Decline of Parathyroid Hormone Level is a Predictor for Post-thyroidectomy Symptomatic Hypocalcemia
The Journal of Endocrine Surgery
2017 .01
-
Clinical and laboratory characteristics of neonatal hypocalcemia
Annals of Pediatirc Endocrinology & Metabolism
2015 .01
-
Investigation of the effect of perioperative parathyroid autotransplantation in incidental parathyroidectomy cases on the development of postoperative hypocalcemia: a retrospective observational study
Annals of Surgical Treatment and Research
2025 .01
-
갑상선유두암에서 갑상선전절제술과 중심경부림프절절제술 후 발생하는 저칼슘혈증 예측 인자 연구
The Journal of Endocrine Surgery
2015 .01
-
Symptomatic Hypocalcemia Associated with Dioscorea tokoro Toxicity
대한임상독성학회지
2019 .01
-
A cell function study on calcium regulation of a novel calcium-sensing receptor mutation (p.Tyr825Phe)
Annals of Pediatirc Endocrinology & Metabolism
2021 .01
-
Severe Vitamin D Deficiency is a Risk Factor of Postoperative Hypocalcemia Following Total Thyroidectomy
대한외과학회 학술대회 초록집
2022 .05
-
부갑상선 점수가 갑상선 전절제술 후 저칼슘혈증을 예측할 수 있을까?
The Journal of Endocrine Surgery
2015 .01
-
Predictors of early postoperative hypocalcemia after total parathyroidectomy in renal hyperparathyroidism
Annals of Surgical Treatment and Research
2020 .01
-
Severe Hypocalcemia in a Patient with Tuberous Sclerosis Complex
Electrolytes & Blood Pressure
2019 .01
-
Perinatal Risk Factors for Early Onset Hypocalcemia in Moderate-to-Late Preterm Infants
Perinatology
2019 .01
-
Prediction of Transient and Permanent Hypoparathyroidism after Total Thyroidectomy Using the Postoperative Serum Parathyroid Hormone Test: When Is the Best Time to Check?
The Journal of Endocrine Surgery
2017 .01
-
Autosomal dominant hypocalcemia with Bartter syndrome due to a novel activating mutation of calcium sensing receptor, Y829C
Korean journal of pediatrics
2015 .01
-
티로신키나아제 억제제 치료 후 발생한 중증 저칼슘혈증및 갑상선기능저하증 1례
International Journal of Thyroidology
2018 .01
-
갑상선암 수술 후 약제 치료: 레보티록신, 칼슘과 비타민 D 맞춤 처방 -최신 가이드라인 중심으로-
대한내과학회지
2017 .06
-
대한갑상선학회 갑상선분화암 진료권고안; Part I. 갑상선분화암의 초기치료 - 제3장 갑상선분화암의 수술 전후 합병증 평가 2024
International Journal of Thyroidology
2024 .05
-
Risk factors of postoperative hypoparathyroidism after total thyroidectomy in pediatric patients with thyroid cancer
Annals of Pediatirc Endocrinology & Metabolism
2023 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2019-514-000759691