지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
In the adult mammalian brain, neural-lineage cells are continuously generated in the subventricular zone (SVZ) and dentate gyrus of the hippocampus. These cells in vivo arising from the adult SVZ may be regulated by environmental enrichment (EE). EE is a method of raising animals in a huge cage containing novel objects, running wheels and social interaction with a complex combination of physical, cognitive, and social stimulations. EE can affect neural plasticity via overexpression of growth factors such as brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), fibroblast growth factor-2 (FGF-2), and synaptic activity-regulating genes. EE also have advanced effects on brain functions including the enhancement of motor and cognitive functions in normal and pathological states. Additionally, behavioral changes by EE are related with molecular changes including neurogenesis, gliogenesis, angiogenesis, axonal sprouting, and dendritic branching in the adult brain. In this review, we focus on brain plasticity and neurorestoration associated with molecular changes of neurotrophic growth factors such as BDNF, VEGF, IGF-1, FGF-2 and synaptic activity-regulating genes that occurs in interaction to EE.
목차
등록된 정보가 없습니다.
참고문헌 (117)
참고문헌 신청
Lee MY / 2013 / Alteration of synaptic activity-regulating genes underlying functional improvement by long-term exposure to an enriched environment in the adult brain / Neurorehabil Neural Repair 27:561~574
Rosenzweig MR / 1978 / Social grouping cannot account for cerebral effects of enriched environments / Brain Res 153:563~576
Mora F / 2007 / Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain / Brain Res Rev 55:78~88
Stein LR / 2016 / Short-term environmental enrichment enhances synaptic plasticity in hippocampal slices from aged rats / Neuroscience 329:294~305
Novkovic T / 2015 / BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment / Hippocampus 25:1~15
Rosenzweig MR / 1978 / Social grouping cannot account for cerebral effects of enriched environments / Brain Res 153:563~576
Mora F / 2007 / Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain / Brain Res Rev 55:78~88
Stein LR / 2016 / Short-term environmental enrichment enhances synaptic plasticity in hippocampal slices from aged rats / Neuroscience 329:294~305
Novkovic T / 2015 / BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment / Hippocampus 25:1~15
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