지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 198 - 204 (7page)
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초록· 키워드
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Purpose: Patent ductus arteriosus (PDA) is common in preterm infants, and about 30% of preterm infants undergo surgical ligation of the PDA. Cardiopulmonary instability, defined as hypotension and respiratory failure after PDA ligation, is reported to occur at a frequency of 40-50%. This study investigated the factors affecting cardiopulmonary instability after PDA ligation in preterm infants.
Methods: The medical records of 45 very low birth weight (VLBW) infants who underwent PDA ligation in the neonatal intensive care unit from January 2009 to December 2013 were analyzed retrospectively. PDA ligation was only performed when medical treatment for hemodynamically significant PDA failed or was contraindicated. The cases were categorized into the hemodynamic instability (n=20) and control (n=25) groups.
Results: Patients underwent ligation at the mean age of 14.3±13.3 days. There were no significant differences between groups in mortality or weaning from ventilation after PDA ligation. In the hemodynamic instability group, birth weight was significantly lower (P=0.046) and the pre-operation C-reactive protein (CRP) level was significantly higher (P=0.042) than in the control group. The use of high-frequency ventilation was higher in the hemodynamic instability group (P=0.033). There were no differences in use of inotropics, mean airway pressure at ligation, timing of ligation, or PDA size between groups. The birth weight and pre-operation CRP level at the time of ligation remained a significant risk factor for cardiopulmonary instability on multiple logistic regression analysis.
Conclusion: In VLBW infants, lower birth weight and a higher pre-operation CRP level are related to unstable conditions after PDA ligation.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Bell MJ / 1978 / Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging / Ann Surg 187 : 1 ~ 7
Benitz WE / 2010 / Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis? / J Perinatol 30 : 241 ~ 252
Clyman RI / 2014 / Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones / J Pediatr 164 : 1449 ~ 1455.e1
Davis P / 1995 / Precision and accuracy of clinical and radiological signs in premature infants at risk of patent ductus arteriosus / Arch Pediatr Adolesc Med 149 : 1136 ~ 1
El-Khuffash AF / 2014 / Assessment and treatment of post patent ductus arteriosus ligation syndrome / J Pediatr 165 : 46 ~ 52.e1
Benitz WE / 2010 / Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis? / J Perinatol 30 : 241 ~ 252
Clyman RI / 2014 / Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones / J Pediatr 164 : 1449 ~ 1455.e1
Davis P / 1995 / Precision and accuracy of clinical and radiological signs in premature infants at risk of patent ductus arteriosus / Arch Pediatr Adolesc Med 149 : 1136 ~ 1
El-Khuffash AF / 2014 / Assessment and treatment of post patent ductus arteriosus ligation syndrome / J Pediatr 165 : 46 ~ 52.e1
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