지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 83 - 87 (5page)
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초록· 키워드
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Purpose: This study aimed to compare cerebral hemispheric volumes between pharmacologic treatment and supportive management of patent ductus arteriosus (PDA).
Methods: The study was conducted retrospectively. The subjects of period 1 group were very low birth weight infants whose PDA were treated with pharmacologic closure. Period 2 group were treated with supportive management. Regional brain volumes measured using magnetic resonance imaging were compared between the two groups.
Results: A total of 12 infants were included. Their median gestational age was 27+6 (range: 24+1–31+1) weeks and birth weight was 1,065 g (range: 690–1,380). Between the two groups, there was no difference in Apgar score, incidence of bronchopulmonary dysplasia, necrotizing enterocolitis, and culture proven sepsis. The regional brain volumes such as gray matter (Period 1 group, 76,833 mm3 [55,759–100,388] vs. Period 2 group, 79,870 mm3 [59,957–113,018], P=0.59), white matter (82,993 mm3 [63,130–121,311] vs. 92,576 mm3 [77,200–104,506], P=0.18), cerebrospinal fluid (17,167 mm3 [9,279–22,760] vs. 14,348 mm3 [7,018–27,604], P=0.94), basal ganglia (2,065 mm3 [1,697 –2,482] vs. 2,306 mm3 [2,065–3,009], P=0.18), and cerebellum (18,374 mm3 [14,843–24,657] vs. 18,096 mm3 [16,134–23,627], P=0.94) were not different between the two groups.
Conclusion: Regional brain volumes were not different between pharmacological and conservative treatment in infants with PDA. Further wellcontrolled studies are required to evaluate the advantages or disadvantages of supportive management without pharmacologic treatment of PDA.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Benitz WE / 2010 / Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis? / J Perinatol 30 : 241 ~ 252
Benitz WE / 2011 / Learning to live with patency of the ductus arteriosus in preterm infants / J Perinatol 31 (Suppl 1) : S42 ~ S48
Bhatt M / 2012 / Does treatment of patent ductus arteriosus with cyclooxygenase inhibitors affect neonatal regional tissue oxygenation? / Pediatr Cardiol 33 : 1307 ~ 1314
Boardman JP / 2006 / Abnormal deep grey matter development following preterm birth detected using deformation-based morphometry / Neuroimage 32 : 70 ~ 78
Clyman RI / 2012 / Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all? / Semin Perinatol 36 : 123 ~ 129
Benitz WE / 2011 / Learning to live with patency of the ductus arteriosus in preterm infants / J Perinatol 31 (Suppl 1) : S42 ~ S48
Bhatt M / 2012 / Does treatment of patent ductus arteriosus with cyclooxygenase inhibitors affect neonatal regional tissue oxygenation? / Pediatr Cardiol 33 : 1307 ~ 1314
Boardman JP / 2006 / Abnormal deep grey matter development following preterm birth detected using deformation-based morphometry / Neuroimage 32 : 70 ~ 78
Clyman RI / 2012 / Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all? / Semin Perinatol 36 : 123 ~ 129
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