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학술저널
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한국심초음파학회 Journal of Cardiovascular Imaging Journal of Cardiovascular Imaging 제25권 제4호
발행연도
2017.1
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131 - 137 (7page)

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Background: To evaluate the outcomes of left ventricular (LV) function according to treatment response for a hemodynamical�ly significant patent ductus arteriosus (hsPDA) in preterm infants. Methods: Echocardiograms of 21 preterm infants born at gestational age < 31 weeks obtained at term-equivalent age were ret�rospectively studied. Among preterm infants with a hsPDA, 9 underwent ligation after failure of pharmacological closure (liga�tion group) and 6 experienced successful pharmacological closure (medication group). Six preterm infants without hsPDA (no�hsPDA group) were studied as controls. LV peak longitudinal systolic strain (ε) of each infant was retrospectively obtained fromechocardiograms using velocity vector imaging, along with neonatal outcomes. Results: Pharmacological closures were attempted at postnatal day 2–3. In the ligation group, the median postnatal age at li�gation was 20 days. In the ligation group, LV peak longitudinal systolic ε was significantly decreased at term-equivalent age com�pared to the other groups. Between the medication and no-hsPDA groups, LV peak longitudinal systolic ε did not differ signifi�cantly. Among the neonatal outcomes, infants who experienced necrotizing enterocolitis (NEC) showed significantly decreasedLV peak longitudinal systolic ε compared to the infants who did not experience NEC . Conclusion: We speculate that in preterm infants with an hsPDA, in cases of medical treatment failure, early PDA ligation atless than 20 days of postnatal age would be beneficial for preserving LV systolic function.

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