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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: The purpose of this study was to calculate the measurement uncertainty of the process of bone mineral density (BMD) analysis using dual energy X-ray absorptiometry with traceability. Methods: Between March 2015 and October 2016, among healthy participants in their 20s and 30s, the study included those who had not taken calcium, vitamin D supplements and steroids and were without a history of osteoporosis, osteopenia and diseases related to osteoporosis. Relational expression of the model was established based on Guide to the Expression of Uncertainty in Measurements and Eurachem and the uncertainty from each factor was evaluated. Results: The combined standard uncertainty was 0.015, while the expanded uncertainty was 0.0298. The factor-specific standard uncertainties that occurred in the process of measuring BMD were 0.72% for the calibration curve, 0.9% for the internal quality control (IQC) using Aluminum Spine Phantom, 0.58% for European Spine Phantom (ESP), and 0.9% for the inspector precision (IP). Conclusions: The combined standard uncertainty of the spine BMD corrected with ESP was 0.015 when measured at one time and targeting one participant. The uncertainties of the accuracy of the IQC and the IP were higher than that of the other factors. Therefore, there will be a need for establishment of protocols to lower these uncertainties.
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참고문헌 (16)
참고문헌 신청
Cox M / 2003 / Evaluation of measurement uncertainty based on the propagation of distributions using Monte Carlo simulation / Meas Tech 46 : 824 ~ 833
Farrance I / 2012 / Uncertainty of measurement: a review of the rules for calculating uncertainty components through functional relationships / Clin Biochem Rev 33 : 49 ~ 75
Genant HK / 1994 / Universal standardization for dual x-ray absorptiometry: patient and phantom cross-calibration results / J Bone Miner Res 9 : 1503 ~ 1514
Goodwin PN / 1987 / Methodologies for the measurement of bone density and their precision and accuracy / Semin Nucl Med 17 : 293 ~ 304
Kalender WA / 1995 / The European spine phantom-a tool for standardization and quality control in spinal bone mineral measurements by DXA and QCT / Eur J Radiol 20 : 83 ~ 92
Farrance I / 2012 / Uncertainty of measurement: a review of the rules for calculating uncertainty components through functional relationships / Clin Biochem Rev 33 : 49 ~ 75
Genant HK / 1994 / Universal standardization for dual x-ray absorptiometry: patient and phantom cross-calibration results / J Bone Miner Res 9 : 1503 ~ 1514
Goodwin PN / 1987 / Methodologies for the measurement of bone density and their precision and accuracy / Semin Nucl Med 17 : 293 ~ 304
Kalender WA / 1995 / The European spine phantom-a tool for standardization and quality control in spinal bone mineral measurements by DXA and QCT / Eur J Radiol 20 : 83 ~ 92
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