지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제20권 제3호
- 발행연도
- 2015.1
- 수록면
- 150 - 154 (5page)
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초록· 키워드
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Purpose: Osteoporosis is currently receiving particular attention as a sequela in survivors of childhood osteosarcoma. The aim of this study was to evaluate bone mineral density (BMD) changes during methotrexate-based chemotherapy in children and adolescents with osteosarcoma.
Methods: Nine patients with osteosarcoma were included in this retrospective study and compared with eight healthy controls. BMD of the lumbar spine and unaffected femur neck of patients was serially measured by dual-energy x-ray absorptiometry (DXA) before and just after chemotherapy and compared with controls.
Results: Four patients (44%) showed decreased lumbar spine BMD and seven patients (78%) showed decreased femur neck BMD, while all controls showed increased lumbar and femur BMD (P=0.024 and P=0.023). The femur neck BMD z-scores decreased from −0.49±1.14 to −1.63±1.50 (P=0.032). At the end of therapy, five patients (56%) showed femur neck BMD z-scores below –2.0.
Conclusion: The bone metabolism is disturbed during therapy in children with osteosarcoma, resulting in a reduced BMD with respect to healthy controls. Since a reduced BMD predisposes to osteoporosis, specific attention and therapeutic interventions should be considered.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Athanassiadou F / 2005 / Evaluation of bone metabolism in children with acute lymphoblastic leukemia after induction chemotherapy treatment / Pediatr Hematol Oncol 22 : 285
Children's Oncology Group / / Long-term follow-up guidelines for survivors of childhood, adolescent, and young adult cancers, ver. 3.0
Cooper C / 2006 / Review: developmental origins of osteoporotic fracture / Osteoporos Int 17 : 337 ~ 347
Goorin AM / 1985 / The Dana Farber Cancer Institute/The children's hospital adjuvant chemotherapy trials for osteosarcoma: three sequential studies / Cancer Treat Symp 3 : 1
Guise TA. / 2006 / Bone loss and fracture risk associated with cancer therapy / Oncologis 11 : 1121 ~ 1131
Children's Oncology Group / / Long-term follow-up guidelines for survivors of childhood, adolescent, and young adult cancers, ver. 3.0
Cooper C / 2006 / Review: developmental origins of osteoporotic fracture / Osteoporos Int 17 : 337 ~ 347
Goorin AM / 1985 / The Dana Farber Cancer Institute/The children's hospital adjuvant chemotherapy trials for osteosarcoma: three sequential studies / Cancer Treat Symp 3 : 1
Guise TA. / 2006 / Bone loss and fracture risk associated with cancer therapy / Oncologis 11 : 1121 ~ 1131
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