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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: Procollagen type I N-terminal propeptide (PINP) is one of the most clinically useful bone formation biomarkers. Therefore, the purpose of this study was to independently evaluate the performance of automated total PINP assay and established age- and gender- specific reference intervals for PINP in healthy Korean population. Methods: The imprecision, linearity, and detection capability of Elecsys total PINP assay was determined and reference interval was established using 599 serums from Korean population with normal bone mineral densities based on bone densitometry. Age groups were divided into 20s, 30s, 40s, 50s, 60s and over. Results: Elecsys total PINP had excellent performance in imprecision, linearity, and detection capability. When partitioning age groups in Korean male and female populations, there was significant difference in total PINP between different age groups. In male populations, PINP level was decreased with increasing age, then it remained steady after middle-age. In female populations, there was a decreasing tendency similar to that in the male population with a sharp increase in the 50 to 59 age group. Conclusions: Elecsys total PINP assay showed precise and reliable performance in our study. We established age-related PINP reference intervals for Korean male and female population with normal bone mineral densities.
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참고문헌 (24)
참고문헌 신청
Kanis JA / 1994 / Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group / Osteoporos Int 4:368~381
하용찬 / 2016 / 한국 골다공증의 역학 / 대한의사협회지 59(11):836~841
박찬호 / 2017 / Change of Bone Mineral Density Measurement among Patients with Osteoporotic Fractures in Korean Population Using National Claim Database / 대한골대사학회지 24(3):183~186
윤병호 / 2018 / Clinical Utility of Biochemical Marker of Bone Turnover: Fracture Risk Prediction and Bone Healing / 대한골대사학회지 25(2):73~78
Hoshino H / 2000 / Changes in levels of biochemical markers and ultrasound indices of Os calcis across the menopausal transition / Osteoporos Int 11:128~133
하용찬 / 2016 / 한국 골다공증의 역학 / 대한의사협회지 59(11):836~841
박찬호 / 2017 / Change of Bone Mineral Density Measurement among Patients with Osteoporotic Fractures in Korean Population Using National Claim Database / 대한골대사학회지 24(3):183~186
윤병호 / 2018 / Clinical Utility of Biochemical Marker of Bone Turnover: Fracture Risk Prediction and Bone Healing / 대한골대사학회지 25(2):73~78
Hoshino H / 2000 / Changes in levels of biochemical markers and ultrasound indices of Os calcis across the menopausal transition / Osteoporos Int 11:128~133
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