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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 14 (14page)
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Selective estrogen receptor modulators (SERMs) are a diverse group of synthetic non-steroidal compounds that have various levels of estrogen receptor (ER) agonist or antagonist activity depending on the target tissue. This feature of SERMs could be explained by the differential expression of two ER isoforms (ERα or ERβ), the differential ER conformational change and the differential coregulatory proteins (coactivator or corepressor) in a selected tissue. Based on their efficacy and safety, SERMs have been used for the prevention and treatment of breast cancer (tamoxifene and toremifene), prevention and treatment of osteoporosis (relaoxifene and bazedoxifene), treatment for dyspareunia related to vulvovaginal atrophy (ospemifene) and treatment for vasomotor symptoms associated with menopause (tissue selective estrogen complex; TSEC). Many of the available SERMs are well-known for their anti-estrogenic effects in breast and for their estrogenic effects in bone. The effect on the endometrium have played a key role in differentiate SERMs in clinical practice. The effect of SERMs in the vagina also shows clear distinction among different SERMs. This review summarizes their action mechanism and describes their clinical findings in different target tissues. In the osteoporosis treatment, SERMs such as raloxifene and bazedoxifene is a safe and effective option for women who cannot tolerate or are unwilling to take bisphosphonates and may be appropriate for younger woman with the age of ≤70 years old who expect to remain on therapy for many years and are concerned about the long-term safety of bisphosphonates.
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참고문헌 (24)
참고문헌 신청
Acconcia F / 2005 / Survival versus apoptotic 17betaestradiol effect: Role of ER alpha and ER beta activated non-genomic signaling / J Cell Physiol 203 : 193 ~ 201
Bolognese MA / 2010 / SERMs and SERMs with estrogen for postmenopausal osteoporosis / Rev Endocr Metab Disord 11 : 253 ~ 259
Cuzick J / 2003 / Overview of the main outcomes in breast-cancer prevention trials / Lancet 361 : 296 ~ 300
Dav
Gizzo S / 2013 / Update on raloxifene:Mechanism of action, clinical efficacy, adverse effects, and contraindications / Obstet Gynecol Surv 68 : 467 ~ 481
Bolognese MA / 2010 / SERMs and SERMs with estrogen for postmenopausal osteoporosis / Rev Endocr Metab Disord 11 : 253 ~ 259
Cuzick J / 2003 / Overview of the main outcomes in breast-cancer prevention trials / Lancet 361 : 296 ~ 300
Dav
Gizzo S / 2013 / Update on raloxifene:Mechanism of action, clinical efficacy, adverse effects, and contraindications / Obstet Gynecol Surv 68 : 467 ~ 481
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