지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 20 - 25 (6page)
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초록· 키워드
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Objectives: Recently, thread-embedding therapy (TET)has been widely applied in Korean medicine for cosmeticpurposes such as reducing skin wrinkles. An insertedthread was reported to have induced continuousstimulation, followed by support for connective tissueregeneration. However, the potential role of TET in hairgrowthhas not yet been reported.
Methods: We designed this study to evaluate whetherTET has a hair-growth-promoting effect. C57 black 6(C57BL/6) mice were divided into three groups: normalsaline-treated, minoxidil-treated, and thread-embeddedgroups. Normal saline or 5% minoxidil was topicallysprayed on the dorsal skin of the mice once a day for 16days. Medical threads were embedded into the dorsalskin of the mice in a single application. Hair growth activitywas evaluated by using dermoscopic and microscopicobservations. Sections of the dorsal skin were stained with hematoxylin and eosin. Expressions ofbromodeoxyuridine (BrdU), proliferating cell nuclearantigen (PCNA), fibroblast growth factor-7 (FGF-7),and fibroblast growth factor-5 (FGF-5) were detectedby using immunohistochemical staining. A reversetranscription-polymerase chain reaction (RT-PCR)analysis was adopted to measure the messenger RNA(mRNA) expressions of FGF-7 and FGF-5.
Results: TET enhanced anagen development in thehair follicles of C57BL/6 mice. The expressions of BrdUand PCNA, both of which imply active cellular proliferation,were increased by using TET. Moreover, TETincreased the expression of FGF-7, an anagen-inducinggrowth factor, while decreasing the expression ofFGF-5, an anagen-cessation growth factor, both at theprotein and the mRNA levels.
Conclusion: TET enhanced hair re-growth in C57BL/6mice. TET regulated the expressions of anagen-associatedgrowth factors and activated the proliferation ofhair follicular cells in depilated skin lesions. Consideringits long-lasting effect, TET may be a good alternativetherapeutic for the treatment of alopecia.
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참고문헌 (28)
참고문헌 신청
[학술지(
Ahmad W / 1998 / Alopecia universalis associated with a mutation in the human hairless gene / Science 279 (5351) : 720 ~ 724
Alexis AF / 2004 / Alopecia areata: autoimmune basis of hair loss / Eur J Dermatol 14 (6) : 364 ~ 370
Ellis JA / 2001 / Polymorphism of the androgen receptor gene is associated with male pattern baldness / J Invest Dermatol 116 (3) : 452 ~ 455
Georgala S / 2007 / Topical use of minoxidil in children and systemic side effects / Dermatology 214 (1) : 101 ~ 102
Ahmad W / 1998 / Alopecia universalis associated with a mutation in the human hairless gene / Science 279 (5351) : 720 ~ 724
Alexis AF / 2004 / Alopecia areata: autoimmune basis of hair loss / Eur J Dermatol 14 (6) : 364 ~ 370
Ellis JA / 2001 / Polymorphism of the androgen receptor gene is associated with male pattern baldness / J Invest Dermatol 116 (3) : 452 ~ 455
Georgala S / 2007 / Topical use of minoxidil in children and systemic side effects / Dermatology 214 (1) : 101 ~ 102
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