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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제16권 제3호
- 발행연도
- 2017.1
- 수록면
- 78 - 82 (5page)
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Background and Purpose Neuropsychiatric symptoms (NPS) such as anxiety, depression, and delusions affect up to 90% of all patients with Alzheimer’s disease (AD). NPS is associated with significant caregiver burden and patient distress. Given the severe burden of NPS in AD, it is critical to know potential modifiable risk factors of NPS in AD. This study explores the association between hypertension and NPS in patients with drug-naïve AD. Methods We reviewed medical records of 149 patients with AD with (n=80) and without (n=69) hypertension. NPS were assessed using the Korean version of Neuropsychiatric Inventory (K-NPI). Affective, psychotic, and behavior symptom clusters were assessed separately. Results The total score of K-NPI was not significantly different between patients with AD with and without hypertension. Among K-NPI domains, scores of depression/dysphoria (p=0.045), anxiety (p=0.022), and apathy/indifference (p=0.037) were significantly higher in patients with AD with hypertension. Systolic blood pressure (BP) was associated with higher total K-NPI and affective symptom cluster scores. Diastolic BP was associated with affective symptom cluster scores. Conclusions Results suggest that hypertension increases risk of specific NPS in patients with AD. Among NPS, hypertension was associated with affective symptom cluster.
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참고문헌 (24)
참고문헌 신청
Ahtiluoto S / 2010 / Diabetes, Alzheimer disease, and vascular dementia:a pop
Choi SH / 2000 / The Korean version of the neuropsychiatric inventory: a scoring tool for neuropsychiatric disturbance in dementia patients / J Korean Med Sci 15 : 609 ~ 615
Choi SH / 2001 / Estimating the validity of the Korean version of expanded clinical dementia rating (CDR) scale / J Korean Neurol Assoc 19 : 585 ~ 591
Elias MF / 1993 / Untreated blood pressure level is inversely related to cognitive functioning: the Framingham Study / Am J Epidemiol 138 : 353 ~ 364
Faraco G / 2013 / Hypertension: a harbinger of stroke and dementia / Hypertension 62 : 810 ~ 817
Choi SH / 2000 / The Korean version of the neuropsychiatric inventory: a scoring tool for neuropsychiatric disturbance in dementia patients / J Korean Med Sci 15 : 609 ~ 615
Choi SH / 2001 / Estimating the validity of the Korean version of expanded clinical dementia rating (CDR) scale / J Korean Neurol Assoc 19 : 585 ~ 591
Elias MF / 1993 / Untreated blood pressure level is inversely related to cognitive functioning: the Framingham Study / Am J Epidemiol 138 : 353 ~ 364
Faraco G / 2013 / Hypertension: a harbinger of stroke and dementia / Hypertension 62 : 810 ~ 817
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