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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제14권 제4호
- 발행연도
- 2015.1
- 수록면
- 168 - 171 (4page)
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초록· 키워드
오류제보하기
Background The described clinical characteristics of early-onset Alzheimer’s disease (EOAD) are distinct from that of late-onset AD. Wereported a patient with atypical EOAD.
Case Report A 54-year-old, truck driver developed gradual visuospatial, language and calculation deficits for 3 months. The neuropsychologicalimpairments were extensive. Brain MRI revealed asymmetric atrophy in left medial temporal lobe along with distinct widening of sylvianfissure. (18)F-florbetapir-positron emission tomography (PET) showed a high uptake in the cortex. Further, the profiles of cerebrospinalfluid (CSF) biomarker were compatible with AD.
Conclusions We diagnosed the patient as EOAD based on the result of biomarker study. Increased Aß burden was identified through amyloidPET imaging and decreased CSF Aβ level. The high rise of CSF Tau proteins was in agreement with the patient’s extensive and rapidcognitive decline. This case report demonstrates the importance of AD biomarker study in confronting early-onset dementia with atypicalclinical presentation.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Adriaanse SM / 2014 / Widespread disruption of functional brain organization in early-onset Alzheimer’s disease / PLoS One 9 : e102995 ~
Damasio H / 1980 / The anatomical basis of conduction aphasia / Brain 103 : 337 ~ 350
Dubois B / 2014 / Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria / Lancet Neurol 13 : 614 ~ 629
Fagan AM / 2012 / Upcoming candidate cerebrospinal fluid biomarkers of Alzheimer’s disease / Biomark Med 6 : 455 ~ 476
Gour N / 2014 / Functional connectivity changes differ in early and late-onset Alzheimer’s disease / Hum Brain Mapp 35 : 2978 ~ 2994
Damasio H / 1980 / The anatomical basis of conduction aphasia / Brain 103 : 337 ~ 350
Dubois B / 2014 / Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria / Lancet Neurol 13 : 614 ~ 629
Fagan AM / 2012 / Upcoming candidate cerebrospinal fluid biomarkers of Alzheimer’s disease / Biomark Med 6 : 455 ~ 476
Gour N / 2014 / Functional connectivity changes differ in early and late-onset Alzheimer’s disease / Hum Brain Mapp 35 : 2978 ~ 2994
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