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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한한방안이비인후피부과학회 한방안이비인후피부과학회지 한방안이비인후피부과학회지 제23권 제1호
발행연도
2010.1
수록면
8 - 22 (15page)

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초록· 키워드

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Objectives : The purpose of this study is to investigate the effects of Gyejijakyakjimo-Tang on the Allergic Contact Dermatitis caused by 2,4-dinitro-chlorobezene(DNCB). Methods : Twenty eight mice were divided into four groups ; normal, control, experimental group A and B. Control and experimental groups were induced allergic contact dermatitis by DNCB. Experimental group A was orally administered the Gyejijakyakjimo-Tang and experimental group B was orally administered the prednisolone. In this study, ear thickness measurement, auricle microphotograph observation,MPO(Myeloperoxidase) activity measurement, Reverse transcription-polymerase chain reaction(RT-PCR) analysis of the mRNA level of TNF-α, IL-1β were performed on these four groups. In addition, the effect of Gyejijakyakjimo-Tang on cell viability and the effect of Gyejijakyakjimo-Tang on the compound 48/80-induced histamine release from HMC and RPMC were measured. Results: 1. Both experimental group A and B had decreased ear thickness compared with control group In contact hypersensitivity assay. 2. In experimental group A, inflammatory edema was similarly observed comparing to control group. Nevertheless, inflammatory edema was obviously reduced in experimental group B. In both experimental group A and B, pathological lesion of dermatitis were alleviated. In addition, the numbers of infiltrated inflammatory cells were decreased compared with control group. 3. Compared to the normal group, there was a noticeable increase in MPO activity in control group. However, in experimental group A and B, it showed remarkable inhibition of the increase in MPO activity comparing with control group. 4. The level of expression of TNF-α, IL-1β in experimental group A and B were meaningfully lower than those in control group. 5. In MTT assay, the concentrations of Gyejijakyakjimo-Tang that were used on the test had no cytotoxicity. 6. Gyejijakyakjimo-Tang dose-dependently inhibited the compound 48/80-induced histamine release from both HMC and RPMC. Conclusions : According to above experiments, Gyejijakyakjimo-Tang was effective on allergic contact dermatitis.
#Gyejijakyakjimo-Tang #Allergic Contact Dermatitis #DNCB #MPO #TNF-α #IL-1β #histamine

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참고문헌 (43)

참고문헌 신청
[학술지(정기 google schola Amy Paller / 2001 / A 12-week study of tacrolimus ointment for the treatment of atopic dermatitis in pediatric pationts / J Am Acad Dermatol 44 : 47 ~ 57 google schola Gunnes G / 2004 / Accumulation of CD25+ CD4+T-cells in the draining lymph node during the elicitation of DNCBinduced contact hypersensitivity in lambs / Research in Veterina google schola Kanemoto, T / 1993 / Supernormal histamine release and normal cytotoxic activity of being rat mast cells with giant granules / Int. Arch. Allergy Immunol 100 : 99 ~ 106 google schola Kataranovski M / 2003 / Immunotoxicity of epicutaneously applied anticoagulant rodenticide warfarin : evaluation by contact hypersensitivity to DNCB in rats / Toxicology 188 google schola

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