지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 46 - 61 (16page)
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초록· 키워드
오류제보하기
Background and Objectives : Allergic Contact Dermatitis is the disease affected by industrialization. The
more industrialization advanced, the more materials that could induce the allergic contact dermatitis have
been increased. Therefore in oriental medicine, various studies have been performed. The objective of this
study is to investigate the effects of Naetakchunkeum-san on the Allergic Contact Dermatitis induced by
2,4-dinitro-chlorobezene(DNCB).
Meterial and Methods : Twenty eight mice were divided into four groups ; normal, control, experimental
group A and B. Control and experimental group were induced allergic contact dermatitis by DNCB.
Experimental group A was orally administered the Naetakchunkeum-san and experimental group B was
orally administered the prednisolone. In this study, ear thickness measurement, observation auricle
microphotograph, Myeloperoxidase(MPO) activity measurement, Reverse transcription-polymerase chain
reaction(RT-PCR) analysis of the mRNA level of TNF-α, IL-1β, INF-γ were performed on these four
groups. In addition, the effect of Naetakchunkeum-san on cell viability and the effect of
Naetakchunkeum-san on the compound 48/80-induced histamine release from HMC and RPMC were
measured.
Results : 1. In contact hypersensitivity assay, experimental group A and B showed decreased ear
thickness compared with control group. 2. In experimental group A, pathological lesion of dermatitis were
alleviated. In addition, the numbers of infiltrated cells were reduced, and cleft was not shown compared
with control group. In experimental group B, similar results were shown. 3. There was a significant increase
in MPO activity in control group compared with normal group. Experimental group A and B significantly
inhibited the increase in MPO activity compared with control group. 4. The level of expression of TNF-α,
IL-1β, INF-γ in experimental group A and B were significantly lower than those in control group. As the
internal control, cyclophilin mRNA was also reverse–transcribed and amplified. 5. In MTT assay, there were
no statistically significant differences in 100 ㎍/㎖, 200 ㎍/㎖, 500 ㎍/㎖, 1000 ㎍/㎖ Naetakchunkeum-san treated group from 0 ㎍/㎖ Naetakchunkeum-san treated group as determined by the Tukey test. 6.
Naetakchunkeum-san dose-dependently inhibited the compound 48/80-induced histamine release from both
HMC and RPMC.
Conclusions : According to above experiments, Naetakchunkeum-san may be applied to allergic contact
dermatitis.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Gunnes G / 2004 / Accumulation of CD25+ CD4+T-cells in the draining lymph node during the elicitation of DNCBinduced contact hypersensitivity in lambs / Research in Veterina
Homey B / 1998 / Topical FK506 Suppresses Cytokine and Costimulatory Molecule Expression in Epidermal and Local Draining Lymph Node Cells During Primary Skin Immune Responses
Kanemoto, T / 1993 / Supernormal histamine release and normal cytotoxic activity of being rat mast cells with giant granules / Int. Arch. Allergy Immunol 100 : 99 ~ 106
Kataranovski M / 2003 / Immunotoxicity of epicutaneously applied anticoagulant rodenticide warfarin : evaluation by contact hypersensitivity to DNCB in rats / Toxicology 188
Kim HH / 2001 / The effect of Yunkyopaedoksangamibang on allergic contact dermatitis. J. Institute Orient Medicine 3 : 67 ~ 80
Homey B / 1998 / Topical FK506 Suppresses Cytokine and Costimulatory Molecule Expression in Epidermal and Local Draining Lymph Node Cells During Primary Skin Immune Responses
Kanemoto, T / 1993 / Supernormal histamine release and normal cytotoxic activity of being rat mast cells with giant granules / Int. Arch. Allergy Immunol 100 : 99 ~ 106
Kataranovski M / 2003 / Immunotoxicity of epicutaneously applied anticoagulant rodenticide warfarin : evaluation by contact hypersensitivity to DNCB in rats / Toxicology 188
Kim HH / 2001 / The effect of Yunkyopaedoksangamibang on allergic contact dermatitis. J. Institute Orient Medicine 3 : 67 ~ 80
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