지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 55 - 60 (6page)
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초록· 키워드
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Objectives : The aim of this study was to evaluate whether herb mixture extract (HME) would affect allergic contact dermatitis induced by 1-chloro-2,4-dinitro-chlorobenzene (DNCB) in mice. For this, the level of blood IgE was identified. To evaluate anti-inflammatory effect of HME, we tested HMC-1 cells stimulated by PMA+A231867. Methods : In order to evaluate allergic contact dermatitis effects we observed HME on contact-hypersensitive skin of Balb/cmice induced by 0.5% DNCB and measured concentration of IgE in blood of Balb/c mice. In order to evaluate anti-inflammatory effect of cytokine expression we used the method of enzyme-linked immunosorbent assay. Results : We confirmed deep wounds, erosions, progress of keratinization and drop out of dead skin cells from Balb/c mice induced by 0.5% DNCB. We also observed a remarkable decrease in symptoms of atopic dermatitis in the group that received injection of 200mg/kg HME. In addition, in the measurement outcome for IgE concentration in blood, we confirmed that IgE concentration was increased by treatment with DNCB only, while it was markedly decreased by treatment with HME. We confirmed that cytokine expression decreased through enzyme-linked immunosorbent assay and pERK, pJNK, and pp38 also decreased through western blot test Conclusions : According to the above results, HME has some effect on alleviating symptoms of allergic contact dermatitis and has anti-inflammatory effects.
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참고문헌 (36)
참고문헌 신청
Cooper KD / 1994 / Atopic dermatitis: Recent trends in pathogenesis and therapy / J Invest Dermatol 102(1):128~138
Leung DY / 2004 / New insights into atopic drmatitis / J Clin Invest 113:651~657
박찬익 / 2006 / 黃芩을 이용한 아토피성 피부용 한방화장품 제형화에 관한 연구 / 대한본초학회지 21(2):47~53
Kang SY / 1978 / Immunoologic aspects of hypersnsitivity diseas in Korea / Seoul J Medicine 19:45~53
Jiang J / 2009 / Oral Administration of Yokukansan Inhibits th Development of Atopic Dermatitis-like Lesions in Isolated NC/Nga Mice / J Dermatol Sci 56(1):37~42
Leung DY / 2004 / New insights into atopic drmatitis / J Clin Invest 113:651~657
박찬익 / 2006 / 黃芩을 이용한 아토피성 피부용 한방화장품 제형화에 관한 연구 / 대한본초학회지 21(2):47~53
Kang SY / 1978 / Immunoologic aspects of hypersnsitivity diseas in Korea / Seoul J Medicine 19:45~53
Jiang J / 2009 / Oral Administration of Yokukansan Inhibits th Development of Atopic Dermatitis-like Lesions in Isolated NC/Nga Mice / J Dermatol Sci 56(1):37~42
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