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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 108 - 117 (10page)
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초록· 키워드
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The oxidative modification of low density lipoprotein(LDL) has been implicated in the development of
atherosclerosis. Oxidized LDL are found in macrophage foam cell, and it can induce an macrophage proliferation
in atherosclerotic plaque. In this study, we investigated the hypothesis that Samkieum may reduce atherosclerosis
by lowering the oxidiazability of LDL,
To achieve this goal, we examined the effect of Samkieum on LDL oxidation, nitric oxide production in
mouse macrophage cell line, RAW264.7, and the effect of Samkieum on cupuric sulfate-induced cytotoxicity,
LDH release, and macrophage activity.
Samkieum inhibited the generation of oxidized LDL from native LDL in RAW264.7 cell culture, and
decreased the release of LDH from cupric sulfate-stimulated RAW264.7 cell. In other experiments, Samkieum
activated RAW264.7 cell, and prolonged the survival time, and increased nitric oxide production in Raw 264.7
cells.
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