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논문 기본 정보

자료유형
학술저널
저자정보
Go, Ahreum (Department of Bioscience and Biotechnology, Sejong University) Ryu, Yun-Kyoung (Department of Bioscience and Biotechnology, Sejong University) Lee, Jae-Wook (Department of Bioscience and Biotechnology, Sejong University) Moon, Eun-Yi (Department of Bioscience and Biotechnology, Sejong University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제21권 제6호
발행연도
2013.1
수록면
481 - 486 (6page)

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Macrophages play a role in innate immune responses to various foreign antigens. Many products from primary tumors influence the activation and transmigration of macrophages. Here, we investigated a migration of macrophages stimulated with cancer cell culture-conditioned medium (CM). Macrophage activation by treatment with CM of B16F10 cells were judged by the increase in protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2). The location where macrophages were at 4 h-incubation with control medium or CM was different from where they were at 5 h-incubation in culture dish. Percentage of superimposed macrophages at every 1 h interval was gradually increased by CM treatment as compared to control. Total coverage of migrated track expressed in coordinates was smaller and total distance of migration was shorter in CM-treated macrophages than that in control. Rac1 activity in CM-treated macrophages was also decreased as compared to that in control. When macrophages were treated with CM in the presence of dexamethasone (Dex), an increase in COX2 protein levels, and a decrease in Rac1 activity and total coverage of migration were reversed. In the meanwhile, biphasic changes were detected by Dex treatment in section distance of migration at each time interval, which was more decreased at early time and then increased at later time. Taken together, data demonstrate that macrophage motility could be reduced in accordance with activation in response to cancer cell products. It suggests that macrophage motility could be a novel marker to monitor cancer-associated inflammatory diseases and the efficacy of anti-inflammatory agents.
#Macrophage #Cell motility #Culture conditioned medium #Dexamethasone

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참고문헌 (25)

참고문헌 신청
Afl aki, E. / 2011 / Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis / Cell. Mol. Life Sci 68:3933~3947 google schola Bailey, C. L. / 2009 / Activation of Rap1 promotes prostate cancer metastasis / Cancer Res 69:4962~4968 google schola Balkwill, F. / 2005 / Smoldering and polarized infl ammation in the initiation and promotion of malignant disease / Cancer Cell 7:211~217 google schola Baruzzi, A. / 2008 / Regulation of phagocyte migration and recruitment by Src-family kinases / Cell. Mol. Life Sci 65:2175~2190 google schola Borisy, G. G. / 2000 / Actin machinery: pushing the envelope / Curr. Opin. Cell Biol 12:104~112 google schola

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