지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 319 - 325 (7page)
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초록· 키워드
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Purpose: Chemerin has been suggested to be linked to insulin resistance and type 2 diabetes mellitus (T2DM). However, the relationshipbetween visceral adiposity and chemerin levels remains unclear in subjects with T2DM. In this study, we investigated the relationship between serum chemerin levels and visceral adiposity.
Materials and Methods: This study included 102 subjects newly diagnosed with T2DM. The relationships between serum chemerin levels and clinical and biochemical parameters were examined. Multiple linear regression analysis was performed to determine the predictable factors of serum chemerin levels.
Results: Serum chemerin levels showed significant positive correlations with body mass index (BMI), waist circumference (WC), visceral fat thickness (VFT), insulin levels, the homeostasis model assessment of insulin resistance, and levels of triglycerides (log-transformed) and high-sensitivity C-reactive protein, while showing significant negative correlations with high-density lipoproteincholesterol. After adjusting for BMI and WC, VFT showed a significant relationship with serum chemerin levels (r=0.222, p=0.027). Moreover, VFT was an independent predictive factor of serum chemerin levels (β=0.242, p=0.041).
Conclusion: We demonstrated that chemerin is linked to metabolic syndrome components. Moreover, serum chemerin levels were associated significantly with obesity, especially visceral adipose tissue, in subjects with T2DM.
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참고문헌 (32)
참고문헌 신청
Jialal I / 2013 / Increased chemerin and decreased omentin-1 in both adipose tissue and plasma in nascent metabolic syndrome / J Clin Endocrinol Metab 98:E514~E517
Gu P / 2014 / Chemerin is associated with inflammatory markers and metabolic syndrome phenotypes in hypertension patients / Clin Exp Hypertens 36:326~332
하유진 / 2011 / Relationship between Chemerin Levels and Cardiometabolic Parameters and Degree of Coronary Stenosis in Korean Patients with Coronary Artery Disease / Diabetes and Metabolism Journal 35(3):248~254
Lin X / 2012 / Elevated serum chemerin levels are associated with the presence of coronary artery disease in patients with type 2 diabetes / Clin Lab 58:539~544
Chaowalit N / 2006 / Subepicardial adipose tissue and the presence and severity of coronary arterydisease / Atherosclerosis 186:354~359
Gu P / 2014 / Chemerin is associated with inflammatory markers and metabolic syndrome phenotypes in hypertension patients / Clin Exp Hypertens 36:326~332
하유진 / 2011 / Relationship between Chemerin Levels and Cardiometabolic Parameters and Degree of Coronary Stenosis in Korean Patients with Coronary Artery Disease / Diabetes and Metabolism Journal 35(3):248~254
Lin X / 2012 / Elevated serum chemerin levels are associated with the presence of coronary artery disease in patients with type 2 diabetes / Clin Lab 58:539~544
Chaowalit N / 2006 / Subepicardial adipose tissue and the presence and severity of coronary arterydisease / Atherosclerosis 186:354~359
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