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Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene
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논문 기본 정보

Type
Academic journal
Author
Journal
Yonsei University College of Medicine Yonsei Medical Journal Yonsei Medical Journal 제58권 제3호 KCI Accredited Journals
Published
2017.1
Pages
557 - 563 (7page)

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Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene
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Purpose: The aim of this study is to investigate the molecular characteristics of occult hepatitis B virus (HBV) infection in ‘anti-HBc alone’ subjects. Materials and Methods: Twenty-four patients with ‘anti-HBc alone’ and 20 control patients diagnosed with HBV were analyzed regardingS and pre-S gene mutations. All specimens were analyzed for HBs Ag, anti-HBc, and anti-HBs. For specimens with an anti-HBc alone, quantitative analysis of HBV DNA, as well as sequencing and mutation analysis of S and pre-S genes, were performed. Results: A total 24 were analyzed for the S gene, and 14 were analyzed for the pre-S gene through sequencing. A total of 20 control patients were analyzed for S and pre-S gene simultaneously. Nineteen point mutations of the major hydrophilic region were found in six of 24 patients. Among them, three mutations, S114T, P127S/T, M133T, were detected in common. Only one mutation was found in five subjects of the control group; this mutation was not found in the occult HBV infection group, however. Pre-S mutations were detected in 10 patients, and mutations of site aa58–aa100 were detected in 9 patients. A mutation on D114E was simultaneouslydetected. Although five mutations from the control group were found at the same location (aa58–aa100), no mutations of occult HBV infection were detected. Conclusion: The prevalence of occult HBV infection is not low among ‘anti-HBc alone’ subjects. Variable mutations in the S gene and pre-S gene were associated with the occurrence of occult HBV infection. Further larger scale studies are required to determinethe significance of newly detected mutations.
#Occult HBV infection #HBV S gene mutation #HBV pre-S gene mutation

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[학술지(정기간행 google schola Allain JP / 2009 / Characterization of occult hepatitis B virus strains in South African blood donors / Hepatology 49 : 1868 ~ 1876 google schola Candotti D / 2012 / Occult hepatitis B infection in blood donors from South East Asia: molecular characterisation and potential mechanisms of occurrence / Gut 61 : 1744 ~ 17 google schola Chen CH / 2009 / A study on sequence variations in pre-S/surface, X and enhancer II/core promoter/precore regions of occult hepatitis B virus in non-B, non-C hepatocellular google schola Coleman PF / 1999 / Immunoassay detection of hepatitis B surface antigen mutants / J Med Virol 59 : 19 ~ 24 google schola

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