VEGF and Ki-67 Overexpression in Predicting Poor Overall Survival in Adenoid Cystic Carcinoma

SEONGYEOL PARK; Soo Jeong Nam; 김범석; 김태민; 전윤경; Se-Hoon Lee; J-Hun Hah; Tack-Kyun Kwon; 김동완; 성명훈; Dae Seog Heo; 방영주

VEGF and Ki-67 Overexpression in Predicting Poor Overall Survival in Adenoid Cystic Carcinoma

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Type: Academic journal

Author: SEONGYEOL PARK Soo Jeong Nam 김범석 김태민 전윤경 Se-Hoon Lee J-Hun Hah Tack-Kyun Kwon 김동완 성명훈 Dae Seog Heo 방영주

Journal: 대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제48권 제2호 KCI Accredited Journals

Published: 2016.1

Pages: 518 - 526 (9page)

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VEGF and Ki-67 Overexpression in Predicting Poor Overall Survival in Adenoid Cystic Carcinoma

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Purpose The purpose of this study was to evaluate potential prognostic factors in patients with adenoid cystic carcinoma (ACC). Materials and Methods A total of 68 patients who underwent curative surgery and had available tissue were enrolled in this study. Their medical records and pathologic slides were reviewed and immunohistochemistry for basic fibroblast growth factor, fibroblast growth factor receptor (FGFR) 2, FGFR3, c-kit, Myb proto-oncogene protein, platelet-derived growth factor receptor beta, vascular endothelial growth factor (VEGF), and Ki-67 was performed. Univariate and multivariate analysis was performed for determination of disease-free survival (DFS) and overall survival (OS). Results In univariate analyses, primary site of nasal cavity and paranasal sinus (p=0.022) and Ki-67 expression of more than 7% (p=0.001) were statistically significant factors for poor DFS. Regarding OS, perineural invasion (p=0.032), high expression of VEGF (p=0.033), and high expression of Ki-67 (p=0.007) were poor prognostic factors. In multivariate analyses, primary site of nasal cavity and paranasal sinus (p=0.028) and high expression of Ki-67 (p=0.004) were independent risk factors for poor DFS, and high expression of VEGF (p=0.011) and Ki-67 (p=0.011) showed independent association with poor OS. Conclusion High expression of VEGF and Ki-67 were independent poor prognostic factors for OS in ACC.

#Adenoid cystic carcinoma #Immunohistochemistry #Vascular endothelial growth factor #Ki-67 #Prognosis

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Gondivkar SM / 2011 / Adenoid cystic carcinoma : a rare clinical entity and literature review / Oral Oncol 47:231~236

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