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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,307 - 1,315 (9page)
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초록· 키워드
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Purpose: The TWIK-related spinal cord K+ channel (TRESK) has recently been discovered and plays an important role in nociceptorexcitability in the pain pathway. Because there have been no reports on the TRESK expression or its function in the dorsal horn of the spinal cord in neuropathic pain, we analyzed TRESK expression in the spinal dorsal horn in a spinal nerve ligation (SNL) model.
Materials and Methods: We established a SNL mouse model by using the L5–6 spinal nerves ligation. We used real-time polymerasechain reaction and immunohistochemistry to investigate TRESK expression in the dorsal horn and L5 dorsal rot ganglion (DRG).
Results: The SNL group showed significantly higher expression of TRESK in the ipsilateral dorsal horn under pain, but low expressionin L5 DRG. Double immunofluorescence staining revealed that immunoreactivity of TRESK was mostly restricted in neuronal cells, and that synapse markers GAD67 and VGlut2 appeared to be associated with TRESK expression. We were unable to find a significant association between TRESK and calcineurin by double immunofluorescence.
Conclusion: TRESK in spinal cord neurons may contribute to the development of neuropathic pain following injury.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Abdulla FA / 2001 / Axotomy- and autotomy-induced changes in Ca2+ and K+ channel currents of rat dorsal root ganglion neurons / J Neurophysiol 85 : 644 ~ 658
Abdulla FA / 2001 / Axotomy- and autotomy-induced changes in the excitability of rat dorsal root ganglion neurons / J Neurophysiol 85 : 630 ~ 643
Abdulla FA / 2002 / Changes in Na(+) channel currents of rat dorsal root ganglion neurons following axotomy and axotomy-induced autotomy / J Neurophysiol 88 : 2518 ~ 2529
Berliocchi L / 2012 / Death in pain: peripheral nerve injury and spinal neurodegenerative mechanisms / Curr Opin Pharmacol 12 : 49 ~ 54
Chaplan SR / 1994 / Quantitative assessment of tactile allodynia in the rat paw / J Neurosci Methods 53 : 55 ~ 63
Abdulla FA / 2001 / Axotomy- and autotomy-induced changes in the excitability of rat dorsal root ganglion neurons / J Neurophysiol 85 : 630 ~ 643
Abdulla FA / 2002 / Changes in Na(+) channel currents of rat dorsal root ganglion neurons following axotomy and axotomy-induced autotomy / J Neurophysiol 88 : 2518 ~ 2529
Berliocchi L / 2012 / Death in pain: peripheral nerve injury and spinal neurodegenerative mechanisms / Curr Opin Pharmacol 12 : 49 ~ 54
Chaplan SR / 1994 / Quantitative assessment of tactile allodynia in the rat paw / J Neurosci Methods 53 : 55 ~ 63
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