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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제4호
- 발행연도
- 2016.7
- 수록면
- 379 - 385 (7page)
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초록· 키워드
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TWIK-related K+ channel-2 (TREK-2) and TWIK-related spinal cord K+ (TRESK) channel are members of two-pore domain K+ channel family. They are well expressed and help to set the resting membrane potential in sensory neurons. Modulation of TREK-2 and TRESK channels are involved in the pathogenesis of pain, and specific activators of TREK-2 and TRESK may be beneficial for the treatment of pain symptoms. However, the effect of commonly used analgesics on TREK-2 and TRESK channels are not known. Here, we investigated the effect of analgesics on TREK-2 and TRESK channels. The effects of analgesics were examined in HEK cells transfected with TREK-2 or TRESK. Amitriptyline, citalopram, escitalopram, and fluoxetine significantly inhibited TREK-2 and TRESK currents in HEK cells (p<0.05, n=10). Acetaminophen, ibuprofen, nabumetone, and bupropion inhibited TRESK, but had no effect on TREK-2. These results show that all analgesics tested in this study inhibit TRESK activity. Further study is needed to identify the mechanisms by which the analgesics modulate TREK-2 and TRESK differently.
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등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Global Burden of Disease Study 2013 Collaborators / 2015 / Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188countries, 1990-2013 : a systematic analysis for the Global Burden of Disease Study 2013 / Lancet 386:743~800
Hall-Flavin DK / 2012 / Using a pharmacogenomic algorithm to guide the treatment of depression / Transl Psychiatry 2:172
Yan J / 2014 / Ion channels and migraine / Headache 54:619~639
Cohen GL / 2005 / Migraine prophylactic drugs work via ion channels / Med Hypotheses 65:114~122
Tsantoulas C / 2014 / Opening paths to novel analgesics : the role of potassium channels in chronic pain / Trends Neurosci 37:146~158
Hall-Flavin DK / 2012 / Using a pharmacogenomic algorithm to guide the treatment of depression / Transl Psychiatry 2:172
Yan J / 2014 / Ion channels and migraine / Headache 54:619~639
Cohen GL / 2005 / Migraine prophylactic drugs work via ion channels / Med Hypotheses 65:114~122
Tsantoulas C / 2014 / Opening paths to novel analgesics : the role of potassium channels in chronic pain / Trends Neurosci 37:146~158
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