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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 350 - 357 (8page)
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Purpose: The detection of high-level tetracycline-resistant strains of Neisseria gonorrhoeae (TRNG) can make important epidemiologicalcontributions that are relevant to controlling infections from this pathogen. In this study, we aimed to determine the incidence of TRNG isolates over time and also to investigate the characteristics and genetic epidemiology of these TRNG isolates in Korea.
Materials and Methods: The antimicrobial susceptibilities of 601 isolates of N. gonorrhoeae from 2004 to 2011 were tested by standard Clinical and Laboratory Standards Institute methods. To determine the molecular epidemiological relatedness, N. gonorrhoeaemulti-antigen sequence typing was performed.
Results: The incidence of TRNG increased from 2% in 2004 to 21% in 2011. The minimum inhibitory concentration distributions of ceftriaxone and susceptibility of ciprofloxacin in TRNG were different from non-TRNG and varied according to the year of isolation.
Most of the TRNG isolates collected from 2004 to 2007 exhibited genetic relatedness, with sequence type (ST) 1798 being the most common. From 2008 to 2011, the STs of the isolates became more variable and introduction of genetically unrelated TRNG were noted.
Conclusion: The increased incidence of TRNG strains until 2007 appears to be due, at least in part, to clonal spread. However, we propose that the emergence of various STs since 2008 could be associated with foreign import.
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참고문헌 (34)
참고문헌 신청
WHO / Global incidence and prevalence of selected curable sexu-ally transmitted infections - 2008
Unemo M / 2013 / Gonorrhoea and gonococcal antimicrobial resistance surveillance networks in the WHO European Region, including the independent countries of the former Soviet Union / Sex Transm Infect 89(Suppl 4):iv42~iv46
Centers for Disease Control and Prevention / Sexually Transmitted Disease Surveillance 2012
Centers for Disease Control and Prevention / Antibiotic Resistance Threats in the United States
Health Insurance Review & Assessment Service / Statistics for Diseases and Treatment in Korea
Unemo M / 2013 / Gonorrhoea and gonococcal antimicrobial resistance surveillance networks in the WHO European Region, including the independent countries of the former Soviet Union / Sex Transm Infect 89(Suppl 4):iv42~iv46
Centers for Disease Control and Prevention / Sexually Transmitted Disease Surveillance 2012
Centers for Disease Control and Prevention / Antibiotic Resistance Threats in the United States
Health Insurance Review & Assessment Service / Statistics for Diseases and Treatment in Korea
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