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논문 기본 정보

자료유형
학술저널
저자정보
Lee Ji Young (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, the Republic of Korea.) Kim Eun Hwa (Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, the Republic of Korea.) Lee Myeongjee (Biostatistics Collaboration Unit, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, the Republic of Korea.) Shin Jehee (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, the Republic of Korea.) Lim Sung Min (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, the Republic of Korea.) Baek Jee Yeon (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, the Republic of Korea.) Kim MinYoung (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, the Republic of Korea.Institute for Immunology and Immunological Disease, Yonsei Univer) Ahn Jong Gyun (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, the Republic of Korea.Institute for Immunology and Immunological Disease, Yonsei Univer) Kang Chung-Min (Department of Pediatric Dentistry, Yonsei University College of Dentistry, Seoul, the Republic of Korea.) Jung Inkyung (Division of Biostatistics, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, the Republic of Korea.) Kang Ji-Man (Department of Pediatrics, Severance Children’s Hospital, Yonsei University College of Medicine, Seoul, the Republic of Korea.Institute for Immunology and Immunological Disease, Yonsei Univer)
저널정보
대한소아감염학회 Pediatric Infection and Vaccine Pediatric Infection and Vaccine 제31권 제1호
발행연도
2024.4
수록면
25 - 36 (12page)
DOI
10.14776/piv.2024.31.e1

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초록· 키워드

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Purpose: Tetracycline is not recommended for children under 12 by guideline due to the risk of tooth discoloration. We aimed to assess the incidence of dental discoloration in Korean children prescribed tetracyclines and investigate whether its risk was greater in tetracycline exposed children than in the general population. Methods: This population-based cohort study using the Health Insurance Review and Assessment service database included children aged 0–12 years exposed to tetracyclines for at least 1 day between January 2008 and December 2020. The primary outcome was the incidence rate of dental discoloration ≥6 months after prescription, and the standardized incidence ratio (SIR) was evaluated as secondary outcome. Results: 56,990 children were included—1,735 and 55,255 aged <8 and 8–12 years, respectively. 61% children were prescribed tetracycline for <14 days with mostly second generation tetracyclines, doxycycline (61%) and minocycline (35%). The 5- and 10-year cumulative incidence rates of dental discoloration were 4.1% (95% confidence interval [CI], 3.0–5.7%) and 5.7% (95% CI, 4.1% to 7.8%), respectively, in the 0–7 years age group and 0.8% (95% CI, 0.7% to 0.9%) and 1.3 (95% CI, 1.1% to 1.4%), respectively, in the 8–12 years age group. Tetracycline exposure did not increase such risk compared to that in the general population (SIR, 1.08; 95% CI, 0.69 to 1.60). Conclusions: The incidence of dental discoloration was lower than previously suggested. Relieving the age restriction for prescribing tetracyclines may be considered.
#Tetracycline #Tooth discoloration #Doxycycline #Minocycline #Korea

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