Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice

정세헌; 김선옥; 조경아; 송승희; 강택원; 박광성; 권동득

Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice

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Type: Academic journal

Author: 정세헌 김선옥 조경아 송승희 강택원 박광성 권동득

Journal: 대한배뇨장애요실금학회 International Neurourology Journal International Neurourology Journal 제19권 제1호 KCI Accredited Journals

Published: 2015.1

Pages: 34 - 38 (5page)

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Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice

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Purpose: It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigatedthe effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identifytheir relation in the urothelium of the urinary bladder. Methods: The cellular localization and expressions of aquaporin 1 and caveolin 1, in the wild type and caveolin 1 knockoutmice urinary bladder, were examined by Western blot and immunofluorescence techniques. Results: Aquaporin 1 and caveolin 1 were coexpressed in the arterioles, venules, and capillaries of the suburothelial layer inthe wild type controls. Aquaporin 1 protein expression was significantly higher in the caveolin 1 knockout mice than in thewild type controls (P<0.05). Conclusions: The results imply that aquaporin 1 and caveolin 1 may share a distinct relation with the bladder signal activity. This might play a specific role in bladder dysfunction.

#Aquaporin 1 #Caveolin 1 #Bladder

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References (21)

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Araki I / 2004 / Overexpression of epithelial sodium channels in epithelium of human urinary bladder with outlet obstruction / Urology 64 : 1255 ~ 1260

Birder LA / 2007 / Mechanisms of disease: involvement of the urothelium in bladder dysfunction / Nat Clin Pract Urol 4 : 46 ~ 54

Cao G / 2003 / Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis / Am J Pathol 162 : 1241 ~ 1248

Cross WR / 2005 / A biomimetic tissue from cultured normal human urothelial cells: analysis of physiological function / Am J Physiol Renal Physiol 289 : F459 ~ F468

Gannon BJ / 2000 / Aquaporin-1 expression in visceral smooth muscle cells of female rat reproductive tract / J Smooth Muscle Res 36 : 155 ~ 167

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