개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.3
- 수록면
- 47 - 54 (8page)
- DOI
- 10.5213/inj.2244236.118
이용수
초록· 키워드
오류제보하기
Purpose: To investigate the effect of detrusor overactivity (DO) on the urethral expression of caveolin (CAV)-1, -2, and -3 of urethra in an animal model of cyclophosphamide (CYP)-induced cystitis rat.
Methods: Female Sprague-Dawley rats were divided into the control group (n=20) and the cystitis group (n=20). Cystitis was induced by intraperitoneal injection of CYP (200 mg/kg). An urodynamic study was done 3 days after the CYP injection to measure functional change of the urinary bladder and urethra. Cellular localization and expression of CAV-1, -2, and -3 in the rat urethra were determined by immunohistochemistry (IHC) and Western blot.
Results: Urodynamic experiments demonstrated a decreased contraction interval in the cystitis group compared to the con trol (3.9±1.0 minutes vs. 6.6±1.2 minutes, P<0.05). Conversely, contraction pressure increased significantly in the cystitis group compared to the control (22.4±0.7 mmHg vs. 11.5±0.4 mmHg, P<0.05). The urethral pressure was decreased in the cystitis group compared to the control (4.05 ±2.5 mmHg vs. 5.8 ±2.8 mmHg, P <0.05). The IHC and Western blot data showed that CAV-1, -2, and -3 expression decreased significantly in the cystitis group compared control group (P<0.05).
Conclusions: The decreased urethral CAV-1, -2, and -3 in the DO rats suggests that CAVs might be related with the function al change of urethra in association with DO of urinay bladder.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Decreased urothelial expression of caveolin 1 and 2 in aging rats showing detrusor overactivity: Potential association with aging bladder
Investigative and Clinical Urology
2021 .11
-
Risk Factor Associated with Recurrence after OM-89 (Uro-Vaxom®) Treatment for Female Recurrent Cystitis
Urogenital Tract Infection
2019 .01
-
여성 방광염에 초점을 맞춘 재발성 요로감염에 대한 인식 제고의 필요성
대한의사협회지
2023 .06
-
Radiation Induced Cystitis and Proctitis - Prediction, Assessment and Management
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
외상성 요도 손상으로 오인된 요도암
한국응급구조학회지
2020 .01
-
National Trends of Antimicrobial Resistance in Uncomplicated Cystitis
Urogenital Tract Infection
2016 .01
-
여성 재발성 요로감염의 진단 및 치료
대한의사협회지
2022 .09
-
Versatile Functions of Caveolin-1 in Aging-related Diseases
전남의대학술지
2017 .01
-
High-definition ultrasound characterization of acute cyclophosphamide-induced cystitis in the mouse
Investigative and Clinical Urology
2020 .01
-
Interstitial Cystitis/Bladder Pain Syndrome: A Urologic Mystery
International Neurourology Journal
2016 .01
-
Novel insight into pressurization of the male and female urethra through application of a multi-channel fibre-optic pressure transducer: Proof of concept and validation
Investigative and Clinical Urology
2020 .01
-
Linguistic and clinical validation of the Turkish version of Acute Cystitis Symptom Score for the diagnosis and patient-reported outcome in acute uncomplicated cystitis
Investigative and Clinical Urology
2023 .05
-
Update on the Pathology and Diagnosis of Interstitial Cystitis/ Bladder Pain Syndrome: A Review
International Neurourology Journal
2016 .01
-
Differences in Urine Microbiome of Acute Cystitis and Chronic Recurrent Cystitis in Women
Urogenital Tract Infection
2023 .04
-
Symptoms of Bacillus Calmette-Guerin Cystitis in Bladder Cancer Patients according to Tuberculosis Sequelae by Chest Radiography
Urogenital Tract Infection
2017 .01
-
Multiparametric Cardiac Magnetic Resonance Imaging Detects Altered Myocardial Tissue and Function in Heart Transplantation Recipients Monitored for Cardiac Allograft Vasculopathy
Journal of Cardiovascular Imaging
2022 .10
-
Increased Expression of Neuregulin 1 and erbB2 Tyrosine Kinase in the Bladder of Rats With Cyclophosphamide-Induced Interstitial Cystitis
International Neurourology Journal
2015 .01
-
Epidemiologic study of bladder and urethral injury in Korea: A nationwide population-based study
Investigative and Clinical Urology
2022 .01
-
Is Urethral Pain Syndrome Really Part of Bladder Pain Syndrome?
Urogenital Tract Infection
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0