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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 82 - 89 (8page)
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Purpose: The 2013 American College of Cardiology (ACC)/American Heart Association (AHA) cholesterol management guidelinesadvocate the use of statin treatment for prevention of cardiovascular disease. We aimed to assess the usefulness of coronary artery calcium (CAC) for stratifying potential candidates of statin use among asymptomatic Korean individuals.
Materials and Methods: A total of 31375 subjects who underwent CAC scoring as part of a general health examination were enrolledin the current study. Statin eligibility was categorized as statin recommended (SR), considered (SC), and not recommended(SN) according to ACC/AHA guidelines. Cox regression analysis was employed to estimate hazard ratios (HR) with 95% confidentialintervals (CI) after stratifying the subjects according to CAC scores of 0, 1–100, and >100. Number needed to treat (NNT) to prevent one mortality event during study follow up was calculated for each group.
Results: Mean age was 54.4±7.5 years, and 76.3% were male. During a 5-year median follow-up (interquartile range; 3–7), there were 251 (0.8%) deaths from all-causes. A CAC >100 was independently associated with mortality across each statin group after adjusting for cardiac risk factors (e.g., SR: HR, 1.60; 95% CI, 1.07–2.38; SC: HR, 2.98; 95% CI, 1.09–8.13, and SN: HR, 3.14; 95% CI, 1.08–9.17). Notably, patients with CAC >100 displayed a lower NNT in comparison to the absence of CAC or CAC 1–100 in SC and SN groups.
Conclusion: In Korean asymptomatic individuals, CAC scoring might prove useful for reclassifying patient eligibility for receiving statin therapy based on updated 2013 ACC/AHA guidelines.
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참고문헌 (35)
참고문헌 신청
Shepherd J / 1995 / Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group / N Engl J Med 333:1301~1307
Cholesterol Treatment Trialists’ (CTT) Collaboration / 2010 / Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials / Lancet 376:1670~1681
Stone NJ / 2014 / 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines / J Am Coll Cardiol 63(25 Pt B):2889~2934
Ridker PM / 2013 / Statins: new American guidelines for prevention of cardiovascular disease / Lancet 382:1762~1765
Vaucher J / 2014 / Population and economic impact of the 2013 ACC/AHA guidelines compared with European guidelines to prevent cardiovascular disease / Eur Heart J 35:958~959
Cholesterol Treatment Trialists’ (CTT) Collaboration / 2010 / Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials / Lancet 376:1670~1681
Stone NJ / 2014 / 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines / J Am Coll Cardiol 63(25 Pt B):2889~2934
Ridker PM / 2013 / Statins: new American guidelines for prevention of cardiovascular disease / Lancet 382:1762~1765
Vaucher J / 2014 / Population and economic impact of the 2013 ACC/AHA guidelines compared with European guidelines to prevent cardiovascular disease / Eur Heart J 35:958~959
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