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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 58 - 62 (5page)
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Purpose: Activation of the innate immune system and chronic low-grade inflammation are thought to be involved in the pathogenesis of atherosclerosis and also thought to be associated with type 2 diabetes and its complications. As a receptor for bacterial lipopolysaccharide and heat-shock proteins, Toll-like receptor 4 (TLR4) is one of the central regulators of the immune response. Recent studies have reported an association between TLR4 polymorphisms and diabetes and its complications in Caucasian populations. Materials and Methods: In this study, we analyzed the association between TLR4 gene polymorphisms in patients with features of type 2 diabetes and healthy controls in Korea. Two polymorphisms of the TLR4 gene (Asp299Gly and Thr399Ile) were examined in 225 diabetic patients and 153 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and single-strand conformation polymorphism (SSCP). Results: No Asp299Gly or Thr399Ile mutations were detected in any of the 378 subjects. Seven subjects from each group who had slightly different SSCP patterns were selected for sequencing, but we found no TLR4 polymorphisms on Exon3. The Asp299Gly and Thr399Ile TLR4 gene polymorphisms were absent in both groups, which was similar to the results for Japanese and Chinese Han subjects. Conclusion: Our data and other Asian data suggest that a racial difference can be found in the frequency of the TLR4 polymorphism.
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참고문헌 (23)
참고문헌 신청
Akira S / 2001 / Toll-like receptors: critical proteins linking innate and acquired immunity / Nat Immunol 2 : 675 ~ 680
Arbour NC / 2000 / TLR4 mutations are associated with endotoxin hyporesponsiveness in humans / Nat Genet 25 : 187 ~ 191
Carr ME / 2001 / Diabetes mellitus: a hypercoagulable state / J Diabetes Complications 15 : 44 ~ 54
Chen S / 2003 / High glucose-induced, endothelin-dependent fibronectin synthesis is mediated via NF-kappa B and AP-1 / Am J Physiol Cell Physiol 284 : c263 ~ c272
Freeman DJ / 2002 / C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study / Diabetes 51 :
Arbour NC / 2000 / TLR4 mutations are associated with endotoxin hyporesponsiveness in humans / Nat Genet 25 : 187 ~ 191
Carr ME / 2001 / Diabetes mellitus: a hypercoagulable state / J Diabetes Complications 15 : 44 ~ 54
Chen S / 2003 / High glucose-induced, endothelin-dependent fibronectin synthesis is mediated via NF-kappa B and AP-1 / Am J Physiol Cell Physiol 284 : c263 ~ c272
Freeman DJ / 2002 / C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study / Diabetes 51 :
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