중이 진주종에서 Toll Like Receptor 2와 4의 발현

조중생; 차창일; 여승근; 이선규; 변재용

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자료유형: 학술저널

저자정보: 조중생 차창일 여승근 이선규 변재용

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제5호

발행연도: 2006.1

수록면: 482 - 487 (6page)

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Background and Objectives：One of the hallmarks of aural cholesteatoma is chronic and recurrent infection. Initiation and perpetuationof the inflammatory response of cholesteatoma may result from an exaggerated host defense reaction of the cholesteatomaepithelium. However, the role of innate immune system in cholesteatoma has not been fully elucidated. Toll-likereceptors (TLRs) are a part of the innate immune system involved in the response to microbial pathogen. TLRs appear torespond to pathogens and induce NF-κB activation. TLR 2 and TLR 4 seem to be related to the initiation of immune responsesagainst gram negative and positive bacteria. We have investigated the expression of TLR 2, and 4 in the normal external auditorycanal skin and cholesteatoma. Subjects and Method：A real time RT-PCR was performed to determine and quantify the expressionof TLR 2 and 4 mRNA. Immunohistochemical staining was performed for 17 cases of cholesteatoma and 8 cases of normalauditory canal skin to demonstrate the distribution of TLR 2 and 4. Results：All cholestatoma and normal external auditory canalskin expressed both TLR 2 and 4 mRNA. The mRNA of TLR 2 and 4 were expressed significantly higher in cholesteatoma thanin the normal external auditory canal skin (p<0.05). Immunohistochemistry using anti-TLR2 and anti-TLR4 antibody revealedthe expression of TLR 2 and 4 in the epithelial cells of the cholesteatoma. Conclusion：These findings suggest that distinctivepatterns of the innate immune related receptors, TLR 2 and 4 system, constitute a part of the innate immune system in the cholesteatoma.(Korean J Otolaryngol 2006;49:482-7)

#Toll 유사 수용체 2·Toll 유사 수용체 4·진주종·중이강. #Toll-like receptor 2·Toll-like receptor 4·Cholesteatoma·Middle ear.

참고문헌 (18)

참고문헌 신청

/ 1985 / Establishment of dorsal-ventral polarity in the Drosophila embryo Genetic studies on therole of the Toll gene product ard c : 779 ~ 89

/ 1997 / Innate immunity: The virtues of a nonclonalsystem of recognition 31 : 295 ~ 298

/ 1997 / Keratinocyte proinflammatoryresponses to adherent and nonadherent group A streptococci 65 : 2119 ~ 2126

/ 1998 / Antimicrobial peptides:An emerging conceptin cutaneous biology 111 : 739 ~ 743

/ 1999 / Differential roles of TLR2 and TLR4 in recognition of gram-negativeand gram-positive bacterial cell wall components 11 : 443 ~ 451

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