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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 337 - 344 (8page)
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초록· 키워드
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Background: Toll-like receptors (TLRs) are expressed by human
epidermal keratinocytes and are involved in immune
responses. Objective: The goal of this was to investigate the
expression of TLR2 in response to bacterial antigens, cytokines,
and different calcium concentrations. Methods: The
expression of TLR2 was assessed after stimulation by lipoteichoic
acid (LTA) and streptolysin O (SLO). In addition,
TLR2 expression was evaluated after treatment with IFN-γ
and TNF-α, and different concentrations of calcium. The expression
levels of TLR2 mRNA and protein were studied using
RT-PCR and Western blot analysis. Results: Cultured human
epidermal keratinocytes constitutively expressed TLR2
and the expression was stimulated by LTA and SLO; in addition,
IFN-γ and TNF-α upregulated TLR2 expression.
However, the changes in TLR2 expression associated with
the calcium concentrations were insignificant. Conclusion:
TLR2 expression increased with the concentration and duration
of bacterial pathogens and this increase was amplified
by several cytokines, from activated keratinocytes and other
cells.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Baker BS / 2003 / Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis / Br J Dermatol 148 : 670 ~ 67
Brightbill HD / 1999 / Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors / Science 285 : 732 ~ 736
Jung HC / 1995 / A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion / J Clin Invest 95 : 55 ~ 65
Kang SS / 2006 / Toll-like receptors: applications to dermatologic disease / J Am Acad Dermatol 54 : 951 ~ 983
Kopp EB / 1999 / The Toll-receptor family and control of innate immunity / Curr Opin Immunol 11 : 13 ~ 18
Brightbill HD / 1999 / Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors / Science 285 : 732 ~ 736
Jung HC / 1995 / A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion / J Clin Invest 95 : 55 ~ 65
Kang SS / 2006 / Toll-like receptors: applications to dermatologic disease / J Am Acad Dermatol 54 : 951 ~ 983
Kopp EB / 1999 / The Toll-receptor family and control of innate immunity / Curr Opin Immunol 11 : 13 ~ 18
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