지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 1 - 6 (6page)
이용수
초록· 키워드
오류제보하기
The primary cause of periodontitis is plaque-associated anaerobic gram-negative bacteria. As shown in the patients with defects in the number or function of neutrophils, innate immunity plays an important role in resistance to bacterial infection and periodontitis. Toll-like receptor 4 (TLR4) is one of the key receptors that recognize the molecular patterns of microbes and initiate innate immune response. To understand the role of TLR4 in the pathogenesis of periodontitis, we investigated whether Asp299Gly of TLR4 mutation is associated with periodontitis in Korean popu-lation. Subjects for this study included 90 healthy subjects and 98 periodontitis patients. The Asp299Gly mutation was screened by PCR-Restriction Fragment Length Polymor-phism (RFLP) of genomic DNA from blood cells using a primer that creates a NcoI restriction site only in the mutant allele. The Asp299Gly mutation was not found in all subjects tested. Our results suggest that the Asp299Gly mutation of TLR4 is very rare in a Korean population. Further mutation screening may be required to determine the role of TLR4 in the pathogenesis of periodontitis
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
/ 1997 / Porphyro-monas gingivalis infection of oral epithelium inhibits neutrophil transepithelial migration 65 : 3983 ~ 3990
/ 1998 / Defective LPS signaling in C3H/HeJ and C57BL /10ScCr mice mutations in Tlr4 gene 282 : 2085 ~ 2088
/ 1998 / IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis 160 : 403 ~ 409
/ 2000 / Phylogenetic variation and polymorphism at the toll-like receptor 4 locus.(TLR4) 1
/ 2000 / TLR4 mutations are associated with endotoxin hypo-responsiveness in humans 25 : 187 ~ 191
/ 1998 / Defective LPS signaling in C3H/HeJ and C57BL /10ScCr mice mutations in Tlr4 gene 282 : 2085 ~ 2088
/ 1998 / IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis 160 : 403 ~ 409
/ 2000 / Phylogenetic variation and polymorphism at the toll-like receptor 4 locus.(TLR4) 1
/ 2000 / TLR4 mutations are associated with endotoxin hypo-responsiveness in humans 25 : 187 ~ 191
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Rarity of TLR4 Asp299Gly and Thr399Ile Polymorphisms in the Korean Population
Yonsei Medical Journal
2008 .01
-
Two Polymorphisms of Interleukin-4 Gene in Korean Adult Periodontitis
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
Link between Periodontal Disease and Diabetes
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .03
-
Profile of chronic and aggressive periodontitis among Senegalese
Journal of Periodontal & Implant Science
2011 .01
-
Prevalence of periodontitis and associated risk factors in Korean adults: Korean National Oral Health Survey 2006
Journal of Periodontal & Implant Science
2009 .01
-
Toll-like Receptors and Innate Immunity
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2011 .12
-
Toll-like Receptors 2 and 4 and Their Mutations in Patients with Otitis Media and Middle Ear Effusion
Clinical and Experimental Otorhinolaryngology
2008 .01
-
만 30세 이상 성인에서 치주염과 고중성지방혈증과의 연관성 : 2015년 국민건강영양조사 자료를 이용하여
한국치위생학회지
2020 .01
-
Neonatal innate immunity and Toll-like receptor
Clinical and Experimental Pediatrics
2010 .01
-
Recapitulation of Genome-wide Association Study on Chronic Periodontitis in a Korean Population
대한의생명과학회지
2017 .06
-
Clinical Significance of Toll-Like Receptor and Toll-Like Receptor Blocker
Urogenital Tract Infection
2016 .01
-
중금속의 혈중 농도와 치주염간의 상관성에 대한 연구 : 제5기 국민건강영양조사 자료 이용
한국치위생학회지
2019 .01
-
Detection of Bacterial Species in Chronic Periodontitis Tissues at Different Stages of Disease Severity
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .12
-
Association between diabetes mellitus and active periodontitis in Korean adults from Korea National Health and Nutrition Examination Surveys 2010–2015
Oral Biology Research
2019 .01
-
FACS and histopathological analyses on neutrophil depletion condition in periodontitis mice model
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Interrelation between plasma membrane calcium ATPase-1 and inflammatory mediators expression in gingival tissue depending on severity of periodontitis
Oral Biology Research
2020 .01
-
TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics
Immune Network
2020 .06
-
Identification of differentially expressed genes using an annealing control primer system in periodontitis
International Journal of Oral Biology
2012 .01
-
중이 진주종에서 Toll Like Receptor 2와 4의 발현
대한이비인후-두경부외과학회지
2006 .01
-
Single Nucleotide Polymorphisms of Toll-Like Receptor 7 and Toll-Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China
Yonsei Medical Journal
2014 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0