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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 489 - 494 (6page)
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Purpose: Prediabetes is an independent risk factor for cardiovascular disease. However, data on the long term adverse clinicaloutcomes of prediabetic patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) arescarce. Materials and Methods: The study population comprised 674 consecutive non-diabetic patients who underwent elective PCI betweenApril 2007 and November 2010. Prediabetes was defined as hemoglobin A1c (HbA1c) of 5.7% to 6.4%. Two-year cumulativeclinical outcomes of prediabetic patients (HbA1c of 5.7% to 6.4%, n=242) were compared with those of a normoglycemic group(<5.7%, n=432). Results: Baseline clinical and angiographic characteristics were similar between the two groups, except for higher glucose levels(104.8±51.27 mg/dL vs. 131.0±47.22 mg/dL, p<0.001) on admission in the prediabetes group. There was no significant differencebetween the two groups in coronary angiographic parameters, except for a higher incidence of diffuse long lesion in the prediabetesgroup. For prediabetic patients, trends toward higher incidences of binary restenosis (15.6% vs. 9.8 %, p=0.066) and late loss(0.71±0.70 mm vs. 0.59±0.62 mm, p=0.076) were noted. During the 24 months of follow up, the incidence of mortality in prediabeticpatients was higher than that in normoglycemic patients (5.5% vs. 1.5%, p=0.007). Conclusion: In our study, a higher death rate and a trend toward a higher incidence of restenosis in patients with prediabetes upto 2 years, compared to those in normoglycemic patients, undergoing elective PCI with contemporary DESs.
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참고문헌 (21)
참고문헌 신청
Bansal N / 2015 / Prediabetes diagnosis and treatment: a review / World J Diabetes 6:296~303
Unwin N / 2002 / Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention / Diabet Med 19:708~723
DeFronzo RA / 2011 / Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose / Am J Cardiol 108(3 Suppl):3B~24B
DECODE Study Group / 2001 / Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria / Arch Intern Med 161:397~405
Corpus RA / 2003 / Relation of hemoglobin A1c to rate of major adverse cardiac events in nondiabetic patients undergoing percutaneous coronary revascularization / Am J Cardiol 92:1282~1286
Unwin N / 2002 / Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention / Diabet Med 19:708~723
DeFronzo RA / 2011 / Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose / Am J Cardiol 108(3 Suppl):3B~24B
DECODE Study Group / 2001 / Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria / Arch Intern Med 161:397~405
Corpus RA / 2003 / Relation of hemoglobin A1c to rate of major adverse cardiac events in nondiabetic patients undergoing percutaneous coronary revascularization / Am J Cardiol 92:1282~1286
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