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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제59권 제4호
발행연도
2018.1
수록면
463 - 469 (7page)

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Moonlighting proteins exhibit multiple activities in different cellular compartments, and their abnormal regulation could play animportant role in many diseases. To date, many proteins have been identified with moonlighting activity, and more such proteinsare being gradually identified. Among the proteins that possess moonlighting activity, several secreted proteins exhibit multipleactivities in different cellular locations, such as the extracellular matrix, nucleus, and cytoplasm. While acute inflammation startsrapidly and generally disappears in a few days, chronic inflammation can last for months or years. This is generally because of thefailure to eliminate the cause of inflammation, along with repeated exposure to the inflammatory agent. Chronic inflammation isnow considered as an overwhelming burden to the general wellbeing of patients and noted as an underlying cause of several diseases. Moonlighting proteins can contribute to the process of chronic inflammation; therefore, it is imperative to overview someproteins that exhibit multiple functions in inflammatory diseases. In this review, we will focus on inflammation, particularly unravellingseveral well-known secreted proteins with multiple functions in different cellular locations.

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