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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,192 - 1,198 (7page)
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Purpose: The optimum local surgical strategy regarding breast-conserving therapy (BCT) for triple-negative breast cancer (TNBC) is controversial. To investigate whether BCT is appropriate for patients with TNBC, we evaluated the clinical outcomes of BCT in women with TNBC compared to those of women without TNBC, using a large, single-center cohort.
Materials and Methods: We performed a retrospective analysis of 1533 women (TNBC n=321; non-TNBC n=1212) who underwentBCT for primary breast cancer between 2000 and 2010. Clinicopathological characteristics, locoregional recurrence-free survival (LRFS), and overall survival (OS) were analyzed.
Results: Tumors from the TNBC group had a higher T stage (T2 37.4% vs. 21.0%, p<0.001), a lower N stage (N0 86.9% vs. 75.5%, p<0.001), and a higher histologic grade (Grade III 66.8% vs. 15.4%, p<0.001) than the non-TNBC group. There were no differences in 5-year LRFS rates between the TNBC and non-TNBC groups (98.7% vs. 97.8%, p=0.63). The non-TNBC group showed a slightly better 5-year OS than the TNBC group; however, the difference was not significant (96.2% vs. 97.3%, p=0.72). In multivariate analyses,TNBC was not associated with poor clinical outcomes in terms of LRFS and OS [hazard ratio (HR) for LRFS=0.37, 95% confidenceinterval (CI): 0.10–1.31; HR for OS=1.03, 95% CI: 0.31–3.39].
Conclusion: TNBC patients who underwent BCT showed non-inferior locoregional recurrence compared to non-TNBC patients with BCT. Thus, BCT is an acceptable surgical approach in patients with TNBC.
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참고문헌 (34)
참고문헌 신청
김지선 / 2014 / The Basic Facts of Korean Breast Cancer in 2011: Results of a Nationwide Survey and Breast Cancer Registry Database / Journal of Breast Cancer 17(2):99~106
Veronesi U / 2002 / Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer / N Engl J Med 347:1227~1232
van Dongen JA / 2000 / Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial / J Natl Cancer Inst 92:1143~1150
Poggi MM / 2003 / Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: the National Cancer Institute Randomized Trial / Cancer 98:697~702
Fisher B / 2002 / Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer / N Engl J Med 347:1233~1241
Veronesi U / 2002 / Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer / N Engl J Med 347:1227~1232
van Dongen JA / 2000 / Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial / J Natl Cancer Inst 92:1143~1150
Poggi MM / 2003 / Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: the National Cancer Institute Randomized Trial / Cancer 98:697~702
Fisher B / 2002 / Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer / N Engl J Med 347:1233~1241
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