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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 141 - 148 (8page)
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초록· 키워드
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The luteinizing hormone-releasing hormone/androgen receptor (LHRH/AR) pathway is a promising treatment target in a subgroup of female patients with triple-negative breast cancer (TNBC). However, very little is known about the efficacy of this strategy in male patients with TNBC. In this report, we describe a male patient with AR-positive TNBC who was successfully treated using an LHRH agonist after pretreatment with several lines of chemotherapy and achieved a durable response. We also review the existing evidence supporting LHRH- and AR-targeted therapy for this rare disease.
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등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Lehmann BD / 2011 / Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies / J Clin Invest 121:2750~2767
Barton VN / 2015 / Multiple molecular subtypes of triple-negative breast cancer critically rely on androgen receptor and respond to enzalutamide in vivo / Mol Cancer Ther 14:769~778
Cardoso F / 2018 / Characterization of male breast cancer : results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program / Ann Oncol 29:405~417
Di Lauro L / 2015 / Androgen receptor and antiandrogen therapy in male breast cancer / Cancer Lett 368:20~25
Gucalp A / 2013 / Phase II trial of bicalutamide in patients with androgen receptor-positive, estrogen receptor-negative metastatic breast cancer / Clin Cancer Res 19:5505~5512
Barton VN / 2015 / Multiple molecular subtypes of triple-negative breast cancer critically rely on androgen receptor and respond to enzalutamide in vivo / Mol Cancer Ther 14:769~778
Cardoso F / 2018 / Characterization of male breast cancer : results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program / Ann Oncol 29:405~417
Di Lauro L / 2015 / Androgen receptor and antiandrogen therapy in male breast cancer / Cancer Lett 368:20~25
Gucalp A / 2013 / Phase II trial of bicalutamide in patients with androgen receptor-positive, estrogen receptor-negative metastatic breast cancer / Clin Cancer Res 19:5505~5512
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