지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,115 - 1,123 (9page)
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초록· 키워드
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Purpose: The systemic inflammation biomarker, Neutrophil-to-Lymphocyte Ratio (NLR), has been reported as one of the adverseprognostic factors for hepatocellular carcinoma (HCC) patient. The purpose of this study was to evaluate whether NLR could predictthe risk of recurrence and death for the HCC patient, according to Milan criteria after hepatectomy.
Materials and Methods: Retrospective analysis was performed on a database of HCC patients who underwent hepatectomy betweenMarch 2001 and December 2011. The cutoff value of NLR was decided by receiver operating characteristic (ROC) curve analysis.
Univariate and multivariate regression analyses were performed to identify predictive factors of recurrence and death.
Results: A total of 213 patients were included in the present study. The median follow-up period was 48 months. One hundred andseven patients were experienced tumor recurrence; forty of them recurred within 12 months (early recurrence). NLR ≥1.505, albumin≤3.75 g/dL, microvascular invasion and high grade of cirrhosis were found to be independent factors for adverse recurrence-freesurvival in multivariate regression analysis. And NLR ≥1.945 was also found as a prognosis factor for early recurrence by univariateregression analysis.
Conclusion: Elevated preoperative NLR can be easily obtained and reliable biomarker for assessing the tumor recurrence and earlyrecurrence of Milan criteria HCC after the initial hepatectomy.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Song IH / 2009 / Current status of liver diseases in Korea: hepatocellular carcinoma / Korean J Hepatol 15(Suppl 6):S50~S59
Park KW / 2008 / Survival analysis of 904 patients with hepatocellular carcinoma in a hepatitis B virus-endemic area / J Gastroenterol Hepatol 23:467~473
김병호 / 2003 / 1990년대 진단된 간세포암의 시기에 다른 임상적 특징 비교 / 대한소화기학회지 42(4)
Minagawa M / 2003 / Selection criteria for repeat hepatectomy in patients with recurrent hepatocellular carcinoma / Ann Surg 238:703~710
Zahorec R / 2001 / Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill / Bratisl Lek Listy 102:5~14
Park KW / 2008 / Survival analysis of 904 patients with hepatocellular carcinoma in a hepatitis B virus-endemic area / J Gastroenterol Hepatol 23:467~473
김병호 / 2003 / 1990년대 진단된 간세포암의 시기에 다른 임상적 특징 비교 / 대한소화기학회지 42(4)
Minagawa M / 2003 / Selection criteria for repeat hepatectomy in patients with recurrent hepatocellular carcinoma / Ann Surg 238:703~710
Zahorec R / 2001 / Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill / Bratisl Lek Listy 102:5~14
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