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Graves' Patient with Thymic Expression of Thyrotropin Receptors and Dynamic Changes in Thymic Hyperplasia Proportional to Graves' Disease Activity
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논문 기본 정보

Type
Academic journal
Author
Journal
Yonsei University College of Medicine Yonsei Medical Journal Yonsei Medical Journal 제57권 제3호 KCI Accredited Journals
Published
2016.1
Pages
795 - 798 (4page)

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Graves' Patient with Thymic Expression of Thyrotropin Receptors and Dynamic Changes in Thymic Hyperplasia Proportional to Graves' Disease Activity
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Thymic hyperplasia is frequently observed in Graves’ disease. However, detectable massive enlargement of the thymus is rare, and the mechanism of its formation has remained elusive. This case showed dynamic changes in thymic hyperplasia on serial computed tomography images consistent with changes in serum thyrotropin receptor (TSH-R) antibodies and thyroid hormone levels. Furthermore,the patient’s thymic tissues underwent immunohistochemical staining for TSH-R, which demonstrated the presence of thymic TSH-R. The correlation between serum TSH-R antibody levels and thymic hyperplasia sizes and the presence of TSH-R in her thymus suggest that TSH-R antibodies could have a pathogenic role in thymic hyperplasia.
#Thymus hyperplasia #graves disease #receptors thyrotropin #immunoglobulins #thyroid-stimulating

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References (10)

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Michie W / 1966 / The thyroid, the thymus and autoimmunity / Br J Clin Pract 20:9~13 google schola Yamanaka K / 2006 / Anterior mediastinal mass in a patient with Graves’ disease / Ann Thorac Surg 81:1904~1906 google schola Popoveniuc G / 2010 / Graves’ disease and thymic hyperplasia: the relationship of thymic volume to thyroid function / Thyroid 20:1015~1018 google schola Suh H / 2013 / Graves’disease and thymic hyperplasia / Surgery 154:1473~1477 google schola Nakamura T / 2004 / A case of thymic enlargement in hyperthyroidism in a young woman / Thyroid 14:307~310 google schola

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