Maternal Thyroid Function during the First Trimester of Pregnancy in Korean Women

최형욱; 한유정; 곽동욱; 박소영; Sung-Hoon Kim; 윤현구; 임창훈

Maternal Thyroid Function during the First Trimester of Pregnancy in Korean Women

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한국여성에서 임신 초기 갑상선기능의 평가

Type: Academic journal

Author: 최형욱 한유정 곽동욱 박소영 Sung-Hoon Kim 윤현구 임창훈

Journal: 대한갑상선학회 International Journal of Thyroidology International Journal of Thyroidology 제10권 제1호 KCI Accredited Journals

Published: 2017.1

Pages: 36 - 41 (6page)

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Maternal Thyroid Function during the First Trimester of Pregnancy in Korean Women

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Background and Objectives: Thyroid dysfunction during pregnancy can result in many complications for both mother and infant. Due to the physiologic changes in thyroid stimulating hormone (TSH) level during early pregnancy, it is recommend to use trimester-specific reference ranges for every population. We obtained the reference range of TSH during the first trimester in Korean women according to gestational week. Materials and Methods: The study population consisted of pregnant women who had undergone a TSH screening during the first trimester of pregnancy (n=8365) and nonpregnant women (n=1835). Results: Median concentration of serum TSH decreased significantly from the 5th to 8th week of gestation (median TSH concentration: 2.00 mIU/L for 5 weeks; 1.70 mIU/L for 6 weeks; 1.40 mIU/L for 7 weeks; 1.05 mIU/L for 8 weeks). However, there was no significant difference in median concentration of serum TSH from the 8th to 12th weeks of gestation. Using the fixed cut-off value of TSH ＞3.66 mIU/L, the diagnosis rate of subclinical hypothyroidism was 15.0% for 5 weeks, 10.0% for 6 weeks, 5.9% for 7 weeks, and 3.6% for 8-12 weeks. Conclusion: When interpreting the TSH test for pregnancy (maternal thyroid function), we should consider that the TSH level decreases significantly during the early first trimester.

#Pregnancy #Reference interval #Thyroid function

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Ballabio M / 1991 / Pregnancy-induced changes in thyroid function: role of human chorionic gonadotropin as putative regulator of maternal thyroid / J Clin Endocrinol Metab 7

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