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논문 기본 정보
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- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제55권 제3호
- 발행연도
- 2021.1
- 수록면
- 230 - 234 (5page)
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Hepatoid thymic carcinoma is an extremely rare subtype of primary thymus tumor resembling “pure” hepatoid adenocarcinomas with hepatocyte paraffin 1 (Hep-Par-1) expression. A 53-year-old man presented with voice change and a neck mass. Multiple masses involving the thyroid, cervical and mediastinal lymph nodes, and lung were detected on computed tomography. Papillary thyroid carcinoma was confirmed by biopsy, and the patient underwent neoadjuvant chemoradiation therapy. However, the anterior mediastinal mass was enlarged after the treatment whereas the multiple masses in the thyroid and neck decreased in size. Microscopically, polygonal tumor cells formed solid sheets or trabeculae resembling hepatocytes and infiltrated remnant thymus. The tumor cells showed immunopositivity for cytokeratin 7, cytokeratin 19, and Hep-Par-1 and negativity for α-fetoprotein. Possibilities of germ cell tumor, squamous cell carcinoma, and metastasis of thyroid papillary carcinoma were excluded by immunohistochemistry. This report on the new subtype of thymic carcinoma is the third in English literature thus far.
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참고문헌 (10)
참고문헌 신청
Travis WD / 2015 / WHO classification of tumours of the lung, pleura, thymus and heart / IARC Press
Franke A / 2004 / Hepatoid thymic carcinoma : report of a case / Am J Surg Pathol 28:250~256
이정현 / 2009 / Hepatoid Thymic Carcinoma - A Case Report - / Journal of Pathology and Translational Medicine 43(6):562~565
Nonaka D / 2008 / Diagnostic utility of thyroid transcription factors Pax8 and TTF-2(FoxE1)in thyroid epithelial neoplasms / Mod Pathol 21:192~200
Su JS / 2013 / Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma : a literature review / World J Gastroenterol 19:321~327
Franke A / 2004 / Hepatoid thymic carcinoma : report of a case / Am J Surg Pathol 28:250~256
이정현 / 2009 / Hepatoid Thymic Carcinoma - A Case Report - / Journal of Pathology and Translational Medicine 43(6):562~565
Nonaka D / 2008 / Diagnostic utility of thyroid transcription factors Pax8 and TTF-2(FoxE1)in thyroid epithelial neoplasms / Mod Pathol 21:192~200
Su JS / 2013 / Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma : a literature review / World J Gastroenterol 19:321~327
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