지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015
- 수록면
- 372 - 375 (4page)
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Background and Purpose Te World Health Organization (WHO) has classifed thymic carcinoma and other thymomas (types A, AB, and B) as diferent neoplasms. Myasthenia gravis (MG) is an early sign of thymoma and theoretically does not accompany thymic carcinoma; however, cases of thymic carcinoma with MG have been reported. Whether thymic carcinoma can accompany MG has yet to be established.
Methods Te medical records of patients who underwent thymectomy for MG between 1990 and 2011 in a single hospital were reviewed. All cases with the diagnostic code of “thymic carcinoma” or “thymoma type C” (old terminology) were selected. A pathologist re-reviewed the pathologic specimens using the new WHO criteria. Te rate of thymic carcinoma among these MG patients was then calculated.
Results A total of 81 patients with MG had thymic tumors, 10 of whom had thymic carcinomas or thymoma type C. Seven cases of well-diferentiated thymic carcinomas (type B3) were excluded, leaving three (3.7%) cases of thymic carcinoma with MG. All three of these cases were type B3 thymoma with a focal squamous cell carcinoma component that was very small and well demarcated. In addition, two out of the three tumors were found to be at an early clinical stage. All of the cases survived without recurrence over follow-up periods of at least 5 years.
Conclusions Tymic carcinoma transformation from thymoma can occur during the early stages of thymoma. Te association of this condition with MG is not as rare as was previously thought. Tymic carcinomas accompanying MG had a predominant B3 thymoma component with a focal thymic carcinoma area (squamous cell carcinoma).
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참고문헌 (20)
참고문헌 신청
Badve S / 2012 / Molecular analysis of thymoma / PLoS One 7 : e42669 ~
Ettinger DS / 2013 / Thymomas and thymic carcinomas: Clinical Practice Guidelines in Oncology / J Natl Compr Canc Netw 11 : 562 ~ 576
Goldstein SD / 2010 / Assessment of robotic thymectomy using the Myasthenia Gravis Foundation of America Guidelines / Ann Thorac Surg 89 : 1080 ~ 1085
Kirchner T / 1992 / Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma / Am J Surg Pathol 16 : 1153 ~ 1169
Kuo TT / 1998 / Thymic carcinoma arising in thymoma is associated with alterations in immunohistochemical profile / Am J Surg Pathol 22 : 1474 ~ 1481
Ettinger DS / 2013 / Thymomas and thymic carcinomas: Clinical Practice Guidelines in Oncology / J Natl Compr Canc Netw 11 : 562 ~ 576
Goldstein SD / 2010 / Assessment of robotic thymectomy using the Myasthenia Gravis Foundation of America Guidelines / Ann Thorac Surg 89 : 1080 ~ 1085
Kirchner T / 1992 / Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma / Am J Surg Pathol 16 : 1153 ~ 1169
Kuo TT / 1998 / Thymic carcinoma arising in thymoma is associated with alterations in immunohistochemical profile / Am J Surg Pathol 22 : 1474 ~ 1481
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