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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 1,008 - 1,016 (9page)
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Purpose: Effect of recombinant human growth hormone (rhGH) administration on lipid storage, and its subsequent effect on insulin sensitivity have not yet been adequately examined. Thus, we investigated the effects of rhGH treatment on muscle triglyceride (TG) and ceramide content, and insulin sensitivity after 4 weeks of rhGH administration in rats.
Materials and Methods: Fourteen rats were randomly assigned to two groups: rhGH injection group (GH, n=7) and saline injection group (CON, n=7). GH received rhGH by subcutaneous injections (130 μg·kg(-1)·day(-1), 6 days·week(-1)) for 4 weeks, while CON received saline injections that were equivalent in volume to GH group. Intramuscular TG and ceramide content and hepatic TG content were measured. To determine insulin sesitivity, oral glucose tolerance test (OGTT) and muscle incubation for glucose transport rate were performed in rats, and used as indicators of insulin sensitivity. We also examined plasm lipid profiles.
Results: After 4 weeks of rhGH treatment, the GH group had higher muscle and liver TG contents than the CON (p<0.05). Ceramide content in GH was significantly greater than that in CON (p<0.05). GH also had higher plasma levels of FFA (p<0.05), glucose and insulin responses during OGTT (p<0.05), and lower glucose transport rates in submaximal insulin concentration (p<0.05) as compared with CON. Results indicate that rhGH treatment is associated with insulin resistance in rats.
Conclusion: rhGH treatment elevated muscle TG and ceramide content, and hepatic TG content. Thus, elevation of these compounde by rhGH treatment could contribute to the development of insulin resistance in rats.
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참고문헌 (24)
참고문헌 신청
Bielawska A / 2001 / Determination of ceramides and diglycerides by the diglyceride kinase assay / Anal Biochem 298 : 141 ~ 150
Binnerts A / 1992 / The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body c
Bramnert M / 2003 / Growth hormone replacement therapy induces insulin resistance by activating the glucose-fatty acid cycle / J Clin Endocrinol Metab 88 : 1455 ~ 1463
Burton AF / 1985 / Increased cholesteryl ester content in liver of mice fed lipid emulsion diets high in polyunsaturated fats / JPEN J Parenter Enteral Nutr 9 : 480 ~ 482
Cartee GD / 1995 / Growth hormone reduces glucose transport but not GLUT-1 or GLUT-4 in adult and old rats / Am J Physiol 268 (5pt1) : E902 ~ E909
Binnerts A / 1992 / The effect of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body c
Bramnert M / 2003 / Growth hormone replacement therapy induces insulin resistance by activating the glucose-fatty acid cycle / J Clin Endocrinol Metab 88 : 1455 ~ 1463
Burton AF / 1985 / Increased cholesteryl ester content in liver of mice fed lipid emulsion diets high in polyunsaturated fats / JPEN J Parenter Enteral Nutr 9 : 480 ~ 482
Cartee GD / 1995 / Growth hormone reduces glucose transport but not GLUT-1 or GLUT-4 in adult and old rats / Am J Physiol 268 (5pt1) : E902 ~ E909
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