지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.3
- 수록면
- 29 - 36 (8page)
이용수
초록· 키워드
오류제보하기
Exercise training is highly correlated with the reduced glucose-stimulated insulin secretion (GSIS), although it enhanced insulin sensitivity, glucose uptake and glucose transporter expression to reduce severity of diabetic symptoms. This study investigated the impact of short-term swimming exercise on insulin regulation in the Goto-Kakizaki (GK) rat as a non-obese model of non-insulin-dependent diabetes mellitus. Wistar (W/S) and GK rats were trained 2 hours daily with the swimming exercise for 4 weeks, and then the changes in the metabolism of insulin and glucose were assessed. Body weight was markedly decreased in the exercised GK rats compare to their non-exercised counterpart, while W/S rats did not show any exercise-related changes. Glucose concentration was not changed by exercise, although impaired glucose tolerance was improved in GK rats 120 min after glucose injection. However, insulin concentration was decreased by swimming exercise as in the decrease of GSIS after running exercise. To identify the other cause for exercise-induced insulin down-regulation, the changes in the levels of key factors involved in insulin production (C-peptide) and clearance (insulin-degrading enzyme; IDE) were measured in W/S and GK rats. The C-peptide level was maintained while IDE expression increased markedly. Therefore, these results showed that insulin down-regulation induced by short-term swimming exercise likely attributes to enhanced insulin clearance via IDE over-expression than by altered insulin production.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (45)
참고문헌 신청
Akiyama H / 1990 / Natural regulatory mechanisms of insulin degradation by insulin degrading enzyme / Biochem Biophys Res Commun 170:1325~1330
Bennett RG / 2000 / Degradation of amylin by insulin-degrading enzyme / J Biol Chem 275:36621~36625
Buemann B / 1996 / Effects of exercise training on abdominal obesity and related metabolic complications / Sports Med 21:191~212
Canas X / 1995 / Rat insulin turnover in vivo / Endocrinology 136:3871~3876
Castillo MJ / 1994 / How to measure insulin clearance / Diabetes Metab Rev 10:119~150
Bennett RG / 2000 / Degradation of amylin by insulin-degrading enzyme / J Biol Chem 275:36621~36625
Buemann B / 1996 / Effects of exercise training on abdominal obesity and related metabolic complications / Sports Med 21:191~212
Canas X / 1995 / Rat insulin turnover in vivo / Endocrinology 136:3871~3876
Castillo MJ / 1994 / How to measure insulin clearance / Diabetes Metab Rev 10:119~150
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2012-510-004225490